Sánchez-Solís de Querol, Manuel

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Sánchez-Solís de Querol, Manuel

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Sánchez-Solís de Querol, Manuel

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Universidad de Murcia. Departamento de Cirugía, Pediatría, Obstetriciay Ginecología

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Risk factors and bronchopulmonary dysplasia severity: data from the Spanish Bronchopulmonary Dysplasia Research Network
(Springer Nature, 2021-10-01) Ramos-Navarro, Cristina; Maderuelo‑Rodríguez, Elena; Concheiro‑Guisán, Ana; Pérez‑Tarazona, Santiago; Rueda‑Esteban, Santiago; Sánchez‑Torres, Ana; Sánchez-Solís de Querol, Manuel; Sanz‑López, Ester; Sánchez‑Luna, Manuel; GEIDIS Research Network; Cirugía, Pediatría y Obstetricia y Ginecología; Facultad de Medicina
GEIDIS is a national-based research-net registry of patients with bronchopulmonary dysplasia (BPD) from public and private Spanish hospitals. It was created to provide data on the clinical characterization and follow-up of infants with BPD until adulthood. The purpose of this observational study was to analyze the characteristics and the impact of perinatal risk factors on BPD severity. The study included 1755 preterm patients diagnosed with BPD. Of the total sample, 90.6% (n = 1591) were less than 30 weeks of gestation. The median gestational age was 27.1 weeks (25.8-28.5) and median birth weight 885 g (740-1,070 g). A total of 52.5% (n = 922) were classified as mild (type 1), 25.3% (n = 444) were moderate (type 2), and 22.2% (n = 389) were severe BPD (type 3). In patients born at under 30 weeks' gestation, most pre-and postnatal risk factors for type 2/3 BPD were associated with the length of exposure to mechanical ventilation (MV). Independent prenatal risk factors were male gender, oligohydramnios, and intrauterine growth restriction. Postnatal risk factors included the need for FiO2 of > 0.30 in the delivery room, nosocomial pneumonia, and the length of exposure to MV. Conclusion: In this national-based research-net registry of BPD patients, the length of MV is the most important risk factor associated with type 2/3 BPD. Among type 3 BPD patients, those who required an FiO2 > .30 at 36 weeks' postmenstrual age had a higher morbidity, during hospitalization and at discharge, compared to those with nasal positive pressure but FiO2 < .30. What is Known: • BPD is a highly complex multifactorial disease associated with preterm birth. What is New: • The length of exposure to mechanical ventilation is the most important postnatal risk factor associated to bronchopulmonary severity which modulate the effect of most pre and postnatal risk factors. • Among patients with BPD, the requirement for FiO2 >.30% at 36 weeks of postmenstrual age is associated with greater morbidity during hospitalization and at discharge.
Open Access
Relationship between lung function and exhaled volatile organic compounds in healthy infants
(Wiley-Blackwell, 2022-01-29) Sola‐Martínez, Rosa A.; Sánchez-Solís de Querol, Manuel; Lozano Terol, Gema; Gallego Jara, Julia; García-Marcos Álvarez, Luis Vicente; Cánovas Díaz, Manuel; Diego Puente, Teresa de; NELA Study Group; Cirugía, Pediatría y Obstetricia y Ginecología; Facultad de Medicina
Objective: The aim of this study is to assess, for the first time, the relationship between the volatilome and lung function in healthy infants, which may be of help for the early detection of certain respiratory diseases. Lung function tests are crucial in chronic respiratory diseases diagnosis. Moreover, volatile organic compounds (VOCs) analysis in exhaled breath is a noninvasive technique that enables the monitorization of oxidative stress, typical of some forms of airway inflammation. Methods: Lung function was studied in 50 healthy infants of 3–8 months of age and the following parameters were obtained: forced vital capacity (FVC), forced ex piratory volume at 0.5 s (FEV0.5), forced expiratory flow at 75% of FVC (FEF75), forced expiratory flow at 25%–75% of FVC (FEF25–75), and FEV0.5/FVC. Lung function was measured according to the raised volume rapid thoracoabdominal compression technique. In addition, a targeted analysis of six endogenous VOCs (acetone, isoprene, decane, undecane, tetradecane, and pentadecane) in the exhaled breath of the children was carried out by means of thermal desorption coupled gas chromatography‐single quadrupole mass spectrometry system. Results: A negatively significant relationship has been observed between levels of acetone, tetradecane, and pentadecane in exhaled breath and several of the lung function parameters. Levels of acetone (feature m/z = 58) were significantly nega tively associated with FVC and FVE0.5, levels of tetradecane (feature m/z = 71) with FEV0.5, and levels of pentadecane (feature m/z = 71) with FEV0.5 and FEF25–75. Conclusion: The findings of this study highlight a significant association between VOCs related to oxidative stress and lung function in healthy infants.
Open Access
Preschool asthma symptoms in children born preterm: the relevance of lung function in infancy
(MDPI, 2020-10-18) Sánchez-Solís de Querol, Manuel; Parra Carrillo, María Soledad; Mondéjar López, Pedro Enrique; García Marcos, Patricia W.; García-Marcos Álvarez, Luis Vicente; Cirugía, Pediatría y Obstetricia y Ginecología; Facultades de la UMU::Facultad de Medicina
Background: The aim of the study is to assess whether lung function of infants born preterm predicts wheezing in pre-school age. Methods: A survey of the core wheezing questionnaire of the International Study on Asthma and Allergy in Children was administered to parents of preterm newborns, to whom lung function tests were performed at a corrected age of six months, and who, at the time of the survey, were between three and nine years of age. Results: Low values of all lung function parameters measured, except FVC, were predictors of wheezing at some time in life, (FEV0.5 OR: 0.62 (95%CI 0.39; 0.995); FEV0.5/FVC OR: 0.73 (0.54; 0.99)) FEF75 OR: 0.60 [0.37; 0.93]; FEF25-75 OR: 0.57 (0.37; 0.89)); and of wheezing in the past year (FEV0.5 OR: 0.36 (0.17; 0.76); FEV0.5/FVC OR: 0.59 (0.38; 0.93); FEF75 OR: 0.38 [0.19; 0.76]; FEF25-75 OR: 0.35 (0.17; 0.70). In addition, FEV0.5/FVC values lower than the lowest limit of normality, were predictive of hospital admissions due to wheezing (OR: 3.07; (1.02; 9.25)). Conclusions: Limited lung function in infancy is predictive of both future wheezing and hospitalization for a wheezing episode.
Open Access
Inherited epigenetic hallmarks of childhood obesity derived from prenatal exposure to obesogens
(MDPI, 2023-03-07) Núñez-Sánchez, María Á.; Jiménez-Méndez, Almudena; Suárez Cortés, María; Martínez-Sánchez, María A.; Sánchez-Solís de Querol, Manuel; Blanco Carnero, José Eliseo; Ruiz Alcaraz, Antonio José; Ramos-Molina, Bruno; Bioquímica y Biología Molecular B e Inmunología; Facultad de Biología
Childhood obesity has reached epidemic levels in developed countries and is becoming a major cause for concern in the developing world. The causes of childhood obesity are complex and multifactorial, involving the interaction between individual genetics and environmental and developmental factors. Among the environmental factors, there is a growing interest in understanding the possible relationship between the so-called environmental obesogens and the development of obesity in children. Exposure to these obesogens such as phthalates, bisphenol A, or parabens, has been identified as a promoter of obesity through different mechanisms such as the alteration of adipocyte development from mesenchymal progenitors, the interference with hormone receptors, and induced inflammation. However, less attention has been paid to the inheritance of epigenetic modifications due to maternal exposure to these compounds during pregnancy. Thus, the aim of this review is to summarize the current knowledge of epigenetic modifications due to maternal exposure to those obesogens during pregnancy as well as their potential implication on long-term obesity development in the offspring and transgenerational inheritance of epiphenotypes.
Open Access
Child head circumference and placental MFSD2a expression are associated to the level of MFSD2a in maternal blood during pregnancy
(Frontiers Media, 2020-02-05) Sánchez-Campillo, María; Ruiz-Palacios, María; Ruiz Alcaraz, Antonio José; Blanco Carnero, José Eliseo; Prieto Sánchez, María Teresa; Zornoza, Matilde; Ruiz-Pastor, María José; Demmelmair, Hans; Sánchez-Solís de Querol, Manuel; Koletzko, Berthold; Larqué Daza, Elvira; Bioquímica y Biología Molecular B e Inmunología; Facultad de Biología
Gestational diabetes mellitus (GDM) is a world-wide health challenge, which prevalence is expected to increase in parallel to the epidemic of obesity. Children born from GDM mothers have lower levels of docosahexaenoic acid (DHA) in cord blood, which might influence their neurodevelopment. Recently, the membrane transporter Major Family Super Domain 2a (MFSD2a) was associated with the selective transportation of DHA as lysophospholipids. The expression of the DHA membrane transporter MFSD2a is lower in GDM placentas, which could affect materno-fetal DHA transport. Humans with homozygous inactivating mutations in the MFSD2a gene present severe microcephalyand intellectual impairments. Herein, we intended to identify early blood biomarkers that maybeofuse during pregnancy to monitor the offspring development and the adequate nutritional interventions, such as nutritional supplementation, that may be selected to improve it. We evaluated MFSD2a expression in maternal blood at the third trimester of pregnancy, and its potential relationship with the expression of placental MFSD2a at delivery and child outcomes. Three groups of pregnant women were recruited: 25 controls, 23 GDM with dietary treatment, and 20 GDM with insulin treatment. Maternal and neonatal anthropometric and biochemical parameters were evaluated. MFSD2a was analyzed in placenta, blood and serum. MFSD2a protein expression in maternal blood was significantly lower in GDM groups and correlated with placental MFSD2a and Z-score neonatal head circumference during the first 6 months of life. The cord/maternal serum ratio of DHA, a solid indicator of materno-fetal DHA transport, was reduced in GDMgroups and correlated with MFSD2a in maternal blood at the third trimester and in placenta at delivery. This indicates that altered MFSD2a levels in maternal blood during pregnancy might influence placental nutrient transport and fetal neurodevelopment. Furthermore, MFSD2a levels in maternal blood on the third trimester were inversely correlated to DHA in maternal serum lyso-PL. Thus, the level of MFSD2a in maternal blood could be used as a potential biomarker for the early detection of disturbances of MFSD2a expression during pregnancy and the subsequent consequences for the neurodevelopment of the child, as well as it may help to choose the optimal treatment approach for the affected subjects.
Open Access
Impact of environmental exposures on exhaled breath and lung function: NELA Birth Cohort
(ERS publications, 2025) Sola-Martínez, Rosa A.; Jiménez Guerrero, Pedro; Sánchez-Solís de Querol, Manuel; Lozano Terol, Gema; Gallego Jara, Julia; Martínez Vivancos, Adrián; Morales Bartolomé, Eva; García-Marcos Álvarez, Luis Vicente; Diego Puente, Teresa de; NELA Study Group; Cirugía, Pediatría y Obstetricia y Ginecología; Facultad de Medicina
Introduction: Exposure to environmental factors (i.e. air pollution and second-hand tobacco smoke) have been associated with impaired lung function. However, the impact of environmental factors on lung health is usually evaluated separately and not with an exposomic framework. In this regard, breath analysis could be a noninvasive tool for biomonitoring of global human environmental exposure. Methods: Data come from 337 mother-child pairs from the Nutrition in Early Childhood Asthma (NELA) birth cohort. Levels of BTEX (benzene, toluene, ethylbenzene and xylenes) in exhaled breath from mothers and children at 3 months after birth were estimated using gas hromatography-mass spectrometry. Short-term residential exposures (breath sampling day and 15 days before breath sampling) to nitrogen dioxide, particulate matter (PM2.5) and ozone were determined by chemical dispersion/transport modelling. Forced vital capacity, forced expiratory volume in 0.5 s (FEV0.5) and forced expiratory flow at 75% of FVC and at 25%-75% of FVC were measured in infants according to the raised-volume rapid thoracoabdominal compression technique. Results: The results showed significant associations between short-term exposure to external agents and levels of benzene and toluene in exhaled breath. It was observed that exhaled levels of benzene and toluene were influenced by smoking status and outdoor air pollution in mothers, and by air pollution in infants (3 months of age). No significant relationship was observed between exposure to maternal tobacco smoking and/or short-term air pollution and lung function in healthy infants. However, there was a significant relationship between FEV0.5 and exhaled toluene in children. Discussion: These findings indicated a significant relationship between environmental exposures and exhaled levels of benzene and toluene, suggesting that breath analysis could be a helpful exposure biomonitoring tool.
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Impact of early caffeine therapy in preterm newborns on infant lung function
(Wiley, 2019-10-06) Sánchez-Solís de Querol, Manuel; García-Marcos, Patricia W.; Agüera‐Arenas, Juan; Mondéjar López, Pedro Enrique; García-Marcos Álvarez, Luis Vicente; Cirugía, Pediatría y Obstetricia y Ginecología; Facultade de Medicina
Objective: To know the effect of caffeine therapy on infant lung function in preterm infants with a gestational age less than 31 weeks. Material and Methods: Forced vital capacity (FVC), forced expiratory volume at 0.5 seconds (FEV0.5), and forced expiratory flows were measured by raised volume rapid thoracoabdominal compression technique; functional residual capacity was measured by plethysmography (FRCpleth). Compliance of the respiratory system was measured by a single interruption technique (Crs). The Student t test was used to compare lung function measurements between the two groups: treated versus nontreated with caffeine. A multivariate analysis was carried out considering each and every lung function parameter (z‐score) as the dependent variable; and gender, gestational age, birth weight (z‐score), corrected age, invasive mechanical ventilation (yes/no), and bronchopulmonary dysplasia (BPD) diagnosis (yes/no) as independent ones. Additionally, stratified analyses by BPD diagnosis were performed. Results: The multivariate analysis showed significant higher z‐scores of FVC and FEV0.5 in preterm infants treated with caffeine (P=.004 and P=.024, respectively). This result only being significant in the group of non‐BPD infants (P=.021 and P=.042), after stratifying by BPD diagnosis. Differences were not found in z‐scores of FEV0.5/FVC, FEF75, FEF25‐75, FRCpleth, nor Crs. Conclusion: Lung function (FVC and FEV0.5) is improved in infants born under 31 weeks of gestation when treated with caffeine. This improvement is driven by the group of infants who did not suffer from BPD. Overall, our results show that there is an early beneficial effect of caffeine treatment in infant lung function.
Open Access
Exhaled volatilome analysis as a useful tool to discriminate asthma with other coexisting atopic diseases in women of childbearing age
(Springer Nature, 2021-07-05) Sola Martínez, Rosa Alba; Lozano Terol, Gema; Gallego Jara, Julia; Morales Bartolomé, Eva; Cantero-Cano, Esther; Sánchez-Solís de Querol, Manuel; García-Marcos Álvarez, Luis Vicente; Jiménez Guerrero, Pedro; Noguera Velasco, José Antonio; Cánovas Díaz, Manuel; Diego Puente, Teresa de; NELA study group; Bioquímica y Biología Molecular B e Inmunología; Cirugía, Pediatría y Obstetricia y Ginecología
The prevalence of asthma is considerably high among women of childbearing age. Most asthmatic women also often have other atopic disorders. Therefore, the diferentiation between patients with atopic diseases without asthma and asthmatics with coexisting diseases is essential to avoid underdiagnosis of asthma and to design strategies to reduce symptom severity and improve quality of life of patients. Hence, we aimed for the frst time to conduct an analysis of volatile organic compounds in exhaled breath of women of childbearing age as a new approach to discriminate between asthmatics with other coexisting atopic diseases and non-asthmatics (with or without atopic diseases), which could be a helpful tool for more accurate asthma detection and monitoring using a noninvasive technique in the near future. In this study, exhaled air samples of 336 women (training set (n= 211) and validation set (n= 125)) were collected and analyzed by thermal desorption coupled with gas chromatography-mass spectrometry. ASCA (ANOVA (analysis of variance) simultaneous component analysis) and LASSO+LS (least absolute shrinkage and selection operator+ logistic regression) were employed for data analysis. Fifteen statistically signifcant models (p-value< 0.05 in permutation tests) that discriminated asthma with other coexisting atopic diseases in women of childbearing age were generated. Acetone, 2-ethyl-1-hexanol and a tetrahydroisoquinoline derivative were selected as discriminants of asthma with other coexisting atopic diseases. In addition, carbon disulfde, a tetrahydroisoquinoline derivative, 2-ethyl-1-hexanol and decane discriminated asthma disease among patients with other atopic disorders. Results of this study indicate that refned metabolomic analysis of exhaled breath allows asthma with other coexisting atopic diseases discrimination in women of reproductive age.
Open Access
Impact of SARS-CoV-2 infection in patients with cystic fibrosis in Spain: Incidence and results of the national CF-COVID19-Spain survey
(2020-06-08) Mondéjar López, Pedro Enrique; Quintana-Gallego, Esther; Girón-Moreno, Rosa M.; Cortell-Aznar, Isidoro; Balbuena-Maiz, Marta Ruiz de; Diab-Cáceres, Layla; Prados-Sánchez, Concepción; Álvarez-Fernández, Antonio; García-Marcos, Patricia W.; Peñalver Mellado, Carlos; Pastor-Vivero, M. Dolores; Olveira, Casilda; López-Neyra, Alejandro; Castillo-Corullón, Silvia; Palma-Milla, Samara; Pérez-Ruiz, Estela; Sole-Jover, Amparo; Barrio, M. Isabel; Sánchez-Solís de Querol, Manuel; Asensio de la Cruz, Óscar; CF-COVID19-Spain Registry Group; Cirugía, Pediatría y Obstetricia y Ginecología; Facultad de Medicina
Background: Given the high incidence of confirmed infection by SARS-CoV-2 and mortality by COVID-19 in the Spanish population, its impact was analysed among persons with Cystic Fibrosis (CF) as a group at risk of a worse evolution. The possible causes of the incidence observed in them are explained and how CF Units have faced this health challenge is detailed. Methods: Retrospective descriptive observational study, for which a Spanish CF Patients with Confirmed COVID- 19 Registry is created, requesting information on number of people affected between 8 March–16 May 2020 and their clinical-demographic characteristics from the CF Units participating in the European Cystic Fibrosis Society Patient Registry (ECFSPR). The accumulated incidence is calculated, compared with that of the general population. Additionally, a survey (CF-COVID19-Spain) is carried out on prevention of SARS-CoV-2 infection, workings of CF Units and possible reasons for the incidence observed. Results: COVID-19 was diagnosed in eight CF patients, one of whom had received a lung transplant. The accu mulated incidence was 32/10000 in CF patients and 49/10000 in the general population. General death rate was 5.85/10000 while no CF patients included in the ECFSPR died. The characteristics of those affected and the results of the survey are described. Conclusions: Despite being considered a disease at high risk of severe COVID-19, the low incidence and mortality in CF patients in Spain contrasts with the figures for the general population. The possible factors that would explain such findings are discussed, with the help of the results of the CF-COVID19-Spain survey.
Open Access
Minimum necessarium. Pathologia Paediatriae. Manual docente de Pediatría II
(Facultad de Medicina, Universidad de Murcia, 2026-05-10) Sánchez-Solís de Querol, Manuel; Ortega García, Juan Antonio; Ortega García, Juan Antonio; Sánchez-Solís de Querol, Manuel; Cirugía, Pediatría y Obstetricia y Ginecología; Manuel Sánchez Solís; Juan Antonio Ortega García; Facultades de la UMU::Facultad de Medicina
Manual docente institucional elaborado para la asignatura Pediatría II del Grado en Medicina de la Facultad de Medicina de la Universidad de Murcia, correspondiente al curso académico 2025–2026. El documento define el mínimo común exigible de conocimientos en Pediatría II y está destinado a estudiantes y profesorado como recurso educativo universitario de apoyo a la docencia. Aborda los principales bloques de la asignatura: aparato respiratorio, sistema cardiovascular, hematología y oncología, endocrinología, sistema nervioso, aparato genitourinario, enfermedades infecciosas, cuidados paliativos, continuidad asistencial y visión global del pediatra. Obra colectiva coordinada por los Profs. Manuel Sánchez Solís y Juan Antonio Ortega García, con la participación de profesores asociados clínicos y profesores colaboradores clínicos de la Universidad de Murcia responsables de los distintos temas.