Publication: Vitamina D durante el embarazo y neurodesarrollo del niño: revisión sistemática
Authors
Villalobos, Marcela ; Tous, Monica ; Canals, Josefa ; Arija, Victoria
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Publisher
Universidad de Murcia
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DOI
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info:eu-repo/semantics/article
Description
Abstract
El déficit de vitamina D durante el embarazo tiene
un impacto negativo en la salud materno-infantil. Objetivo: Evaluar el
efecto del estado de vitamina D durante el embarazo sobre el neurodesa-
rrollo del niño. Selección de estudios: Se realizó una búsqueda de la litera-
tura científica publicada en PubMed/MEDLINE, Scopus y Cochrane has-
ta enero del 2018. Se seleccionaron los estudios que relacionaban el estado
de la vitamina D durante el embarazo con algún dominio del neurodesa-
rrollo del niño (mental, motor, lenguaje, cociente intelectual y comporta-
miento). La calidad de los estudios incluidos se evaluó a través de la escala
Newcastle-Ottawa. Resultados: De los 164 estudios encontrados en la bús-
queda, once estudios cumplieron los criterios y fueron considerados diez
de alta calidad metodológica y uno de moderada. La revisión sistemática
mostró que niveles prenatales de vitamina D <50 nmol/L se asocian fre-
cuentemente a un peor desarrollo mental, motor y del lenguaje de sus hijos
en comparación con las madres con concentraciones ≥50 nmol/L. Conclu-
sión: Aunque existe poca evidencia científica que corrobore la relación entre
la deficiencia de vitamina D prenatal y su impacto en el neurodesarrollo de
los hijos, los datos actuales sugieren un perjuicio sobre el desarrollo mental,
motor y del lenguaje del niño.
Background: A deficiency of vitamin D during pregnancy has a negative impact on maternal-infant health. Objective: To evaluate the effect of vitamin D status during pregnancy on offspring neurodevelopmental outcomes. Selection of studies: We explored studies that linked maternal vit- amin D status with offspring neurodevelopmental outcomes. The studies selected were identified by systematically reviewing the scientific literature published in PubMed/MEDLINE, Scopus and Cochrane until January 2018. The quality of the studies was evaluated using the Newcastle-Ottawa scale. Results: 164 studies were identified and reviewed for selection. This systematic review, which comprises eleven studies (ten of a high methodo- logical quality and one moderate), shows that mothers with vitamin D lev- els <50 nmol/L during pregnancy had offspring with poorer mental, mo- tor and language development compared to mothers with concentrations ≥50 nmol/L. Conclusion: There is still not enough scientific evidence to confirm the relationship between prenatal vitamin D deficiency and off- spring neurodevelopmental outcomes. However, recent data suggest a det- rimental effect on the mental, motor and language development of off- spring.
Background: A deficiency of vitamin D during pregnancy has a negative impact on maternal-infant health. Objective: To evaluate the effect of vitamin D status during pregnancy on offspring neurodevelopmental outcomes. Selection of studies: We explored studies that linked maternal vit- amin D status with offspring neurodevelopmental outcomes. The studies selected were identified by systematically reviewing the scientific literature published in PubMed/MEDLINE, Scopus and Cochrane until January 2018. The quality of the studies was evaluated using the Newcastle-Ottawa scale. Results: 164 studies were identified and reviewed for selection. This systematic review, which comprises eleven studies (ten of a high methodo- logical quality and one moderate), shows that mothers with vitamin D lev- els <50 nmol/L during pregnancy had offspring with poorer mental, mo- tor and language development compared to mothers with concentrations ≥50 nmol/L. Conclusion: There is still not enough scientific evidence to confirm the relationship between prenatal vitamin D deficiency and off- spring neurodevelopmental outcomes. However, recent data suggest a det- rimental effect on the mental, motor and language development of off- spring.
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