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Escolar Reina, Pilar

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Escolar Reina, Pilar
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Universidad de Murcia. Departamento de Fisioterapia
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    Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon
    (eLife Sciences Publications, 2022-02-24) Peñin Franch, Alejandro; García Vidal, José Antonio; Escolar Reina, Pilar; Martínez Ojeda, Rosa M. ; Gómez, Ana I.; Bueno García, Juan Manuel; Minaya-Muñoz, Francisco; Valera-Garrido, Fermín; Escolar Reina, Pilar; Bueno García, Juan Manuel; Medina i Mirapeix, Francesc; Martínez Cáceres, Carlos Manuel; Fisioterapia
    The NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathic lesions, different non-resolving mechanisms produce a degenerative condition that impairs tissue healing and which therefore complicates their clinical management. Percutaneous needle electrolysis consists of the application of a galvanic current and is an emerging treatment for tendinopathies. In the present study, we found that galvanic current activates the NLRP3 inflammasome and induces an inflammatory response that promotes a collagen-mediated regeneration of the tendon in mice. This study establishes the molecular mechanism of percutaneous electrolysis that can be used to treat chronic lesions and describes the beneficial effects of an induced inflammasome-related response.
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    Open Access
    Mobility limitations related to reduced pulmonary function amongaging people with chronic obstructive pulmonary disease
    (Plos One, 2018-05-01) Medina i Mirapeix, Francesc; Bernabeu Mora, Roberto; Sánchez Martínez, Mª Piedad; Montilla Herrador, Joaquina; Myriam Bernabeu Mora; Escolar Reina, Pilar; Fisioterapia; Facultades de la UMU::Facultad de Medicina
    Background Chronic obstructive pulmonary disease (COPD) is a major cause of disability. We aimed to analyse the impact of reduced pulmonary function on non-respiratory impairments and mobility activity limitations in an elderly population with COPD and to elucidate which spe cific limitations on mobility are related to reduced pulmonary function Methods Cross-sectional study of 110 patients with COPD, recruited from public and university hospi tal. The effect of impaired pulmonary function on the risk of non-respiratory impairments and mobility limitations was analysed using validated measures, including: the 6-Minute Walk Test (6MWT), skeletal muscle strength, the Short Physical Performance Battery (SPPB), andself-reported mobility questionnaire. Multivariate analysis was used to control for con founders such as age, sex, height, education, and cigarette smoking. Results Greater impairment of pulmonary function was associated with less distance walked during the 6MWT,poorerSPPBscores,andgreater risk of self-reported mobility limitations (p<0.05). Lower forced expiratory volume in 1 s was also associated with a greater risk of limitations in carrying items under 10 pounds (4.54 kg), walking alone up and down a flight of stairs, and walking two or three neighbourhood blocks. There was no clear statistical rela tionship between pulmonary function impairment and skeletal muscle strength. Conclusions Impaired pulmonary function was associated with the 6MWT score and limitations on perfor mance-based and self-reported mobility activities, but not with skeletal muscle strength amongelderly COPDpatients
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