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Almaida Pagán, Pedro Francisco

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Almaida Pagán, Pedro Francisco
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Universidad de Murcia. Departamento de Fisiología
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    Evaluating the Accuracy of Declared Eating Schedules by Continuous Glucose Monitoring
    (2026-02-27) González Romero, Pedro; Madrid Pérez, Juan Antonio; Almaida Pagán, Pedro Francisco; Rol de Lama, María de los Ángeles; Sin departamento asociado; Facultades de la UMU::Facultad de Biología
    Background/Objectives: Chrononutrition is an emergent field concerning the effect of eating patterns on human health and their relationship with biological rhythms. Current evidence points towards the benefits of early eating in the prevention of non-communicable diseases and circadian health. Despite the importance of eating/fasting rhythm, current methods are neither specific nor validated against physiological variables. This work aimed to explore an objective metabolic outcome, postprandial glucose, as an accuracy indicator of self-declared meal schedules registered in a mobile app. Methods: A 1-week protocol of ambulatory monitoring of meal schedules, glucose, and circadian variables was performed in 20 young adults. Meal annotations were registered using KronoEat 1.0, a smartphone app, allowing for both prospective and recall entries. A circadian monitoring device provided data on movement intensity, distal skin temperature, and prospective food annotation. Results: Participants annotated an average of 3.5 food events/day/participant with KronoEat. Breakfast (92.7%) and lunch (86.4%) showed the highest proportion of food events related to a glycemic excursion, whereas this proportion was lower for dinner (79.7%) and snacks (67.7%). Postprandial glucose after main meals differed significantly from average glucose levels. Interesting couplings were found in circadian variables and glucose—for example, between post-breakfast glycemic excursions and the morning increase in activity. Conclusions: Meal schedules registered under free-living conditions in KronoEat show high levels of correlation with postprandial glucose and glycemic excursions derived from continuous glucose monitoring.
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    Correction: Circadian system functional status and sleep in blind subjects with and without conscious light perception
    (Frontiers Media, 2026-04-13) Martínez Martínez, David; González Romero, Pedro; Rodríguez Morilla, Beatriz; Bonmatí Carrión, María de los Ángeles; Rol de Lama, María de los Ángeles; Almaida Pagán, Pedro Francisco; Fisiología; Facultades de la UMU::Facultad de Biología
    To understand circadian rhythms and sleep in an understudied population, which is particularly prone to suffer chronodisruption (CD), eighteen blind volunteers of 51.5 ± 3.6 years (Mean ± SEM) and 26 volunteers (51.8 ± 1.2) with no visual impairments wore the ambulatory circadian monitoring (ACM) device Kronowise® for seven consecutive days in real-life conditions. Nine of the blind participants declared to have some sort of light perception while the other nine declared to lack conscious light perception. ACM combines measurements of distal skin temperature; motor activity, light exposure and feeding schedules, providing information about lifestyle and the bidirectional crosstalk between internal time and external synchronisers, which is paramount to determine a subject’s CD degree. We found a extraordinarily diverse population in terms of blindness aetiology and thus, in the degree of affectation of the participants visual and circadian systems. Our results pointed to poorer circadian health and sleep in the blind participants, which could be directly related to the impact of disease over circadian photoreception but also to disruption of daily habits. Compared to controls, blind participants showed significantly lower light exposure and physical activity values during the day and higher time of movement during the night. Besides, we analysed feeding schedules in the blind participants for the first time and found that their last meal of the day happened later than in controls, thus blind participants’ night fasting was shorter. Altogether, our results indicated substantial behavioural circadian alterations associated with the disease.
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