Browsing by Subject "cascade reaction"
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- PublicationOpen AccessPd-catalyzed cascade reactions involving skipped dienes: from double carbopalladation to remote C–C cleavage(2019-08-05) Azizollahi, Hamid; P. Mehta, Vaibhav; García-López, José-Antonio; Química InorgánicaWe report two ligand-controlled cascade reactions relying on the intramolecular carbopalladation of skipped dienes. The use of a bulky monodentate phosphine ligand affords [4,5]-spirocycles via sequential double carbopalladation, however bidentate phosphines promote a remote β-C-elimination process which does not rely on the use of strained or sterically hindered substrates
- PublicationOpen AccessSynthesis of spiro-oxoindoles through Pd-catalyzed remote C–H alkylation using alpha-diazocarbonyl compounds(2017-02-10) Pérez-Gómez, Marta; Hernández-Ponte, Sergio; Bautista, Delia; García-López, José-Antonio; Química InorgánicaIn this communication we describe a new route to spiro-oxoindoles derivatives through a novel Pd-catalyzed cascade process. This reaction is based on the remote C–H activation performed by sigma-alkyl Pd(II) species generated in situ via intramolecular carbopalladation of alkenes, followed by insertion of a carbenoid coupling partner.