Browsing by Subject "RNA binding protein"

Now showing 1 - 2 of 2
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    Beyond an oncogene, Lin28 is a master regulator of cancer progression
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2018) Wang, Xuefei; Weng, Mingjiao; Jin, Yinji; Yang, Weiwei; Wang, Xin; Wu, Di; Wang, Tianzhen; Li, Xiaobo
    The RNA binding protein Lin28 is increased in most human malignancies, and elevated Lin28 is a biomarker for poor prognosis and contributes to cancer progression. Lin28 functions as a master oncogene and is involved in almost all hallmarks of cancer. In this review, we summarize the aberrant molecular expression mechanisms and pathological roles of Lin28 in cancer progression. Moreover, we elaborate on the established molecular mechanisms, from the transcriptional level to the post-transcriptional and translational levels, by which Lin28 regulates cancer progression.
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    Circular RNAs: Characteristics, function and role in human cancer
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2018) Chen, Shuo; Zhao, Yang
    Circular RNAs (circRNAs) are universal and diverse endogenous noncoding RNAs (ncRNAs) that are widely found in eukaryotic cells. They form a covalently closed, continuous stable loop structure without 3' or 5' tails, which are different from linear RNAs. As new members of the ncRNAs, circRNAs’ formation, function, and mechanism are attracting increased research attention. CircRNAs play important roles in all kinds of cancer and may be potential novel biomarkers and therapeutic targets for cancer treatment through their function as microRNA (miRNA) molecular “sponges”, RNA-binding protein (RBP) sponges, protein translators, and gene transcription regulators. In this review, we introduce the formation and function of circRNAs, and summarize the biological effects of circRNA in tumorigenesis and progression, providing evidence for the potential use of circRNAs in the diagnosis and clinical treatment of cancer.