Publication:
Beyond an oncogene, Lin28 is a master regulator of cancer progression

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Wang-33-327-334-2018.pdf(156.86 KB)
Date
2018
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Authors
Wang, Xuefei ; Weng, Mingjiao ; Jin, Yinji ; Yang, Weiwei ; Wang, Xin ; Wu, Di ; Wang, Tianzhen ; Li, Xiaobo
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Publisher
Universidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­a
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DOI
DOI: 10.14670/HH-11-922
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info:eu-repo/semantics/article
Description
Abstract
The RNA binding protein Lin28 is increased in most human malignancies, and elevated Lin28 is a biomarker for poor prognosis and contributes to cancer progression. Lin28 functions as a master oncogene and is involved in almost all hallmarks of cancer. In this review, we summarize the aberrant molecular expression mechanisms and pathological roles of Lin28 in cancer progression. Moreover, we elaborate on the established molecular mechanisms, from the transcriptional level to the post-transcriptional and translational levels, by which Lin28 regulates cancer progression.
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Lin28 , RNA binding protein , Oncogene , Cancer progression
Citation
Histology and Histopathology, Vol.33, nÂş4, (2018)
URI
http://hdl.handle.net/10201/118783
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Histology and histopathology Vol.33, nÂş4 (2018)
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