Publication: Circular RNAs: Characteristics, function and role in human cancer
Authors
Chen, Shuo ; Zhao, Yang
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-969
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info:eu-repo/semantics/article
Description
Abstract
Circular RNAs (circRNAs) are universal and
diverse endogenous noncoding RNAs (ncRNAs) that are
widely found in eukaryotic cells. They form a covalently
closed, continuous stable loop structure without 3' or 5'
tails, which are different from linear RNAs. As new
members of the ncRNAs, circRNAs’ formation,
function, and mechanism are attracting increased
research attention. CircRNAs play important roles in all
kinds of cancer and may be potential novel biomarkers
and therapeutic targets for cancer treatment through their
function as microRNA (miRNA) molecular “sponges”,
RNA-binding protein (RBP) sponges, protein translators,
and gene transcription regulators. In this review, we
introduce the formation and function of circRNAs, and
summarize the biological effects of circRNA in
tumorigenesis and progression, providing evidence for
the potential use of circRNAs in the diagnosis and
clinical treatment of cancer.
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Citation
Histology and Histopathology, Vol.33, nº9, (2018)
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/