Browsing by Subject "Pomegranate"

Now showing 1 - 3 of 3
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    Assessing the impact of (poly)phenol-rich foods on cardiometabolic risk in postmenopausal women: a dietary trial
    (MDPI, 2024-08-09) SĂĄnchez-MartĂ­nez, Lorena; GarcĂ­a-Alonso, Javier; Mena, Pedro; Periago, MarĂ­a JesĂșs; GonzĂĄlez-Barrio, RocĂ­o; TecnologĂ­a de Alimentos, NutriciĂłn y BromatologĂ­a
    Menopause is a critical stage in a woman’s life in which cardiometabolic alterations appear, such as insulin resistance or a predisposition to visceral fat deposits, leading to an increased risk of cardiometabolic diseases (R-CMBs). New strategies to reduce the R-CMBs in postmenopausal women using natural compounds without adverse effects are desirable. In this sense, plant-based diets rich in fruits and vegetables could play a fundamental role due to the high content of bioactive compounds found in these diets, such as (poly)phenols, known for their antioxidant, anti-inflammatory and vasodilator properties. The aim of this research was to carry out a dietary trial to evaluate the effect of the daily intake of different (poly)phenol-rich foods (PP-rich foods) for 2 months on the modulation of the main cardiometabolic risk biomarkers of postmenopausal women. The results showed a slight improvement in blood pressure (BP), lipid profile and oxidative stress, endothelial function and inflammatory biomarkers. These findings suggest that daily consumption of PP-rich foods alleviated the R-CMBs of postmenopausal women by reducing the oxidative stress and, thus, the risk of cardiovascular events; however, the magnitude of the cardioprotective effect of (poly)phenols depends on inter-individual variability.
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    MicroRNAs expression in normal and malignant colon tissues as biomarkers of colorectal cancer and in response to pomegranate extracts consumption: critical issues to discern between modulatory effects and potential artefacts
    (Wiley, Wiley-VCH Verlag, 2015-07-20) NĂșñez SĂĄnchez, MarĂ­a A.; DĂĄvalos, Alberto; GonzĂĄlez-SarrĂ­as, Antonio; Casas-Agustench, Patricia; Visioli, Francesco; Monedero Saiz, Tamara; GarcĂ­a Talavera, Noelia V.; GĂłmez SĂĄnchez, MarĂ­a B.; SĂĄnchez-Álvarez, Carmen; GarcĂ­a-Albert, Ana M.; RodrĂ­guez-Gil, Francisco J.; Ruiz-MarĂ­n, Miguel; Pastor Quirante, Francisco A.; MartĂ­nez DĂ­az, Francisco; TomĂĄs-BarberĂĄn, Francisco A.; GarcĂ­a-Conesa, MarĂ­a Teresa; EspĂ­n, Juan Carlos; OftalmologĂ­a, OptometrĂ­a, OtorrinolaringologĂ­a y AnatomĂ­a PatolĂłgica
    Scope: MicroRNAs (miRs) are proposed as colorectal cancer (CRC) biomarkers. Pomegranate ellagic acid and their microbiota metabolites urolithins exert anticancer effects in preclinical CRC models, and target normal and malignant colon tissues in CRC patients. Herein, we investigated whether the intake of pomegranate extract (PE) modified miRs expression in surgical colon tissues versus biopsies from CRC patients. Methods and results: We conducted a randomized, double-blind, controlled trial. Thirty-five CRC patients consumed 900 mg PE daily before surgery. Control CRC patients (no PE intake, n = 10) were included. Our results revealed: (1) significant differences for specific miRs between malignant and normal tissues modifiable by the surgical protocols; (2) opposed trends between -5p and -3p isomolecules; (3) general induction of miRs attributable to the surgery; (4) moderate modulation of various miRs following the PE intake, and (5) no association between tissue urolithins and the observed miRs changes. Conclusion: PE consumption appears to affect specific colon tissue miRs but surgery critically alters miRs levels hindering the discrimination of significant changes caused by dietary factors and the establishment of genuine differences between malignant and normal tissues as biomarkers. The components responsible for the PE effects and the clinical relevance of these observations deserve further research.
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    Targeted metabolic profiling of pomegranate polyphenols and urolithins in plasma, urine and colon tissues from colorectal cancer patients
    (Wiley, Wiley-VCH Verlag, 2014-02-16) NĂșñez SĂĄnchez, MarĂ­a Angeles; GarcĂ­a-Villalba, RocĂ­o; Monedero Saiz, Tamara; GarcĂ­a-Talavera, Noelia V.; GĂłmez SĂĄnchez, MarĂ­a B.; SĂĄnchez-Álvarez, Carmen; GarcĂ­a-Albert, Ana M.; RodrĂ­guez-Gil, Francisco J.; Ruiz-MarĂ­n, Miguel; Pastor Quirante, Francisco A.; MartĂ­nez DĂ­az, Francisco; Yåñez-GascĂłn, MarĂ­a J.; GonzĂĄlez-SarrĂ­as, Antonio; TomĂĄs-BarberĂĄn, Francisco A.; EspĂ­n, Juan C.; OftalmologĂ­a, OptometrĂ­a, OtorrinolaringologĂ­a y AnatomĂ­a PatolĂłgica
    Scope: Urolithins are bioactive metabolites produced by the gut microbiota from ellagitannins (ETs) and ellagic acid (EA). We investigated whether urolithins could be detected in colon tissues from colorectal cancer (CRC) patients after pomegranate extract (PE) intake. Methods and results: CRC patients (n = 52) were divided into controls and PEs consumers (900 mg/day for 15 days) before surgical resection. PEs with low (PE-1) and high (PE-2) punicalagin:EA ratio were administered. Twenty-three metabolites, but no ellagitannins, were detected in urine, plasma, normal (NT) or malignant (MT) colon tissues using UPLC-ESI-QTOF-MS/MS (UPLC, ultra performance liquid chromatography; QTOF, quadrupole TOF). Free EA, five EA conjugates, gallic acid and 12 urolithin derivatives were found in colon tissues. Individual and total metabolites levels were higher in NT than in MT, independently of the PE consumed. The maximal mean concentration (1671 ± 367 ng/g) was found in NT after consumption of PE-1 and the lowest concentration (42.4 ± 10.2 ng/g) in MT with PE-2. Urolithin A or isourolithin A were the main urolithins produced (54 and 46% patients with urolithin A or isourolithin A phenotype, respectively). High punicalagin content (PE-2) hampered urolithins formation. Conclusion: Significant levels of EA derivatives and urolithins are found in human colon tissues from CRC patients after consumption of pomegranate. Further studies are warranted to elucidate their biological activity.