Browsing by Subject "Metabolic syndrome"

Now showing 1 - 5 of 5
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    Apoptosis and proliferation of the prostate cells in men with benign prostatic hyperplasia and concomitant metabolic disorders
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2018) Rył, Aleksandra; Rotter, Iwona; Kram, Andrzej; Teresiński, Leszek; Słojewski, Marcin; Dołęgowska, Barbara; Lubkowska, Anna; Piasecka, Małgorzata; Laszczyńska, Maria
    Introduction. Apoptosis and proliferation of prostate cells are associated with both physiological increase and hyperplasia of the prostate. The aim of this study was to determine the contribution of metabolic syndrome to the processes of apoptosis and proliferation in gland epithelial cells and prostatic stromal cells in men with BPH. Materials and methods. The study involved 151 men, aged 52-89 years, receiving pharmacological treatment for BPH. The men were divided into two groups: those with and those without metabolic syndrome. The serum levels of the parameters were determined. Reactions for the identification of apoptosis (TUNEL) and proliferation (PCNA) in cells were also performed. Results. The relationships between the number of TUNEL(+) and PCNA(+) cells and metabolic syndrome were not observed. It was found that the total number of TUNEL(+) cells in the prostate stroma correlated negatively with the levels of highdensity lipoprotein and insulin-like growth factor-1. The analysis of the correlations in BPH patients with and without metabolic syndrome demonstrated that the only parameter correlating with the number of PCNA(+) cells in the prostate stroma was insulin resistance. Conclusion. Metabolic syndrome in patients with BPH had no impact on the number of TUNEL(+) and PCNA(+) cells in the prostate gland. However, the disturbed levels of metabolic parameters, and deviations of anthropometric parameters from normal may influence the number of apoptotic and proliferating cells.
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    Evaluation of Commercial Carob Syrups (Ceratonia siliqua L.) in Randomized Controlled Trials: Effects on Lipid, Glycaemic, and Anthropometric Parameters
    (MDPI, 2025-10-28) Planes Muñoz, David; Rosell, María de los Ángeles; Frontela Saseta, María del Carmen; López Nicolás, Rubén; Tecnología de Alimentos, Nutrición y Bromatología
    Background: Metabolic disorders such as diabetes and dyslipidaemia are intricately connected to dietary habits. This has resulted in an increasing interest in functional foods that may offer benefits for glycaemic and lipid regulation. This study aims to evaluate the effects of two commercial carob syrups on postprandial glycaemic response, serum lipid profile, and anthropometric measurements in healthy adults. Methods: The research comprised two complementary randomized and controlled trials: (i) a glycaemic test involving 20 volunteers and (ii) a six-week intervention that assessed serum cholesterol levels and body composition in a cohort of 72 participants. Volunteers were between the ages of 18 and 65 years in both studies. Results: Both syrups displayed statistical significance in low glycaemic indices (GI = 56.04 ± 13.75, and 60.46 ± 26.92%) and an attenuation of the postprandial glucose response by 16% compared to glucose control (p < 0.05). Furthermore, daily consumption of carob syrup was associated with a statistically significant reduction, p < 0.05, in total cholesterol and waist circumference: −14.68 ± 25.60 mg/dL and −3.58 ± 1.79 cm, respectively. These effects are attributed to the bioactive compounds naturally present in carobsyrup, particularly D-pinitol and polyphenols, which may play a role in modulating insulin sensitivity and lipid metabolism. Conclusions: These findings indicate that carob syrups may serve as promising functional ingredients with a reduced glycaemic impact and potential cardiometabolic benefits. However, they should be interpreted as preliminary evidence. The novelty of the present study lies mainly in the use of commercially available syrups in a healthy cohort, where effects on lipids and anthropometry were modest but consistent.
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    Identification of changes in serum analytes and possible metabolic pathways associated with canine obesity-related metabolic dysfunction
    (Elsevier, 2019-02) Tvarijonaviciute, Asta; Barić Rafaj, R.; Horvatic, A.; Muñoz Prieto, A.; Guillermin, N.; Tumpa, A.; Cerón, J. J.; Martínez Subiela, S.; Mrljak, V.; Medicina y Cirugía Animal
    The main objective of this study was to identify analytes that could change and that could help to clarify the metabolic and physiopathological changes related to canine obesity-related metabolic dysfunction (ORMD). For this, serum from 35 overweight/obese dogs, with and without ORMD, was submitted to a comprehensive panel of biochemistry analysis, a gel-free tandem mass tag isobaric label-based proteomic analysis, and, finally, selected proteins were used as a starting point for creating a protein interaction network. Dogs with ORMD showed significantly higher serum concentrations of alanine aminotransferase (ALT), alkaline phosphatase (ALP), Ca, total proteins, albumin, total cholesterol, triglycerides, glucose, and butyrylcholinesterase (BChE) activity in comparison with dogs without ORMD. Proteomic analysis revealed that 23 proteins related to lipid metabolism, the complement factor system, cellular adhesion and functionality, inflammation, and coagulation were altered in dogs with ORMD. Finally, the obtained protein interaction network highlighted that the central term of this network was the negative regulation of the immune response. These data suggest that canine ORMD is associated with changes in analytes that reflect altered lipid metabolism, and liver and immune function impairment and suggests the potential for a prothrombotic state and lung function alterations.
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    Influencia de la actividad física y los hábitos nutricionales sobre el riesgo de síndrome metabólico
    (Universidad de Murcia, 2016) Arandojo Morales, María Isabel; Pacheco Delgado, Valeriano; Morales Bonilla, José Antonio
    La conjunción de varios factores de riesgo originados por la obesidad, el sedentarismo o por diversos factores genéticos, lleva a padecer el llamado “Síndrome Metabólico”, que incrementa la posibilidad de desarrollar enfermedades cardiovasculares. Objetivos: Describir el riesgo de padecer enfermedades cardiovasculares que tienen los miembros de la Guardia Civil de un complejo militar de Madrid. Material y método: Estudio descriptivo transversal, realizado mediante encuesta de 30 preguntas, analítica y medidas antropométricas al personal de la Guardia Civil que acudió al servicio médico de su acuartelamiento entre el 1 de septiembre y el 31 de octubre de 2014. Resultados: Muestra de 76 sujetos de entre 20 y 62 años. El 7’89% de los individuos tiene tres o más parámetros para el diagnóstico del Síndrome Metabólico. Conclusiones: El sedentarismo y los malos hábitos nutricionales actúan negativamente en el perfil lipídico, TA y el IMC de los individuos, haciendo que estos tengan más probabilidades de padecer SM y, por tanto, enfermedades cardiovasculares.
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    The role of high cholesterol-high fructose diet on coronary arteriosclerosis
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2016) Swier, Vicki J.; Tang, Lin; Radwan, Mohamed M.; Hunter III, William J.; Agrawa, Devendra K.
    The effect of fructose in conjunction with high cholesterol diet in the development of atherosclerotic lesions in coronary arteries is not well established. Microswine were fed high cholesterol (HC) or a high cholesterol-high fructose (HCHF) diet containing 18-20% calories from fructose. All swine had high levels of serum cholesterol and non-HDL, thickened intima and accumulation of collagen in the coronaries. Swine fed with HC diet had less stenosis in coronary arteries, lower serum levels of non-HDL, triglycerides, cholesterol, and blood glucose than HCHF group. Coronary lesions in the HC swine were not as progressed as in HCHF and showed low LDL-expressed lipid-laden foam cells. The M1/M2 macrophage phenotype in the HCHF swine differed with the progression of atherosclerosis, with higher density of M1-phenotype in HCHF swine. There was high expression of CCR7 (M1-phenotype) in more advanced lesions in the fibrous cap-like areas, whereas M2- macrophages were abundant in the foam-cell cores. These findings suggest that the addition of a fructose to high cholesterol diet accelerates atherosclerotic lesions in coronary arteries with an increase in M1-macrophages and the propensity to develop features of metabolic syndrome.