Browsing by Subject "Induced pluripotent stem cells"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Open Access
    In vitro differentiation of primordial germ cells and oocyte-like cells from stem cells
    (Universidad de Murcia. Departamento de Biología Celular e Histología, 2018) Costa, José J.N.; Souza, Glaucinete B.; Soares, Maria A.A.; Ribeiro, Regislane P.; van den Hurk, Robert; Silva, José R.V.
    Infertility is the result of failure due to an organic disorder of the reproductive organs, especially their gametes. Recently, much progress has been made on generating germ cells, including oocytes, from various types of stem cells. This review focuses on advances in female germ cell differentiation from different kinds of stem cells, with emphasis on embryonic stem cells, adult stem cells, and induced pluripotent stem cells. The advantages and disadvantages of the derivation of female germ cells from several types of stem cells are also highlighted, as well as the ability of stem cells to generate mature and functional female gametes. This review shows that stem cell therapies have opened new frontiers in medicine, especially in the reproductive area, with the possibility of regenerating fertility.
  • Thumbnail Image
    Publication
    Open Access
    Patient iPSC-derived retinal organoids: Observable retinal diseases in-a-dish
    (Universidad de Murcia, Departamento de Biologia Celular e Histiologia, 2021) Zhang, Xiao-Hui; Jin, Zi-Bing
    Induced pluripotent stem cells (iPSCs), reprogrammed from human somatic cells, hold the capacity to differentiate into most human body cells. iPSCs can be differentiated into retinal organoids, a three-dimensional structured retina containing various retinal cells. Patient-specific retinal organoids provide a powerful disease model to recapitulate the disease to study the pathogenesis of inherited retinal dystrophies, to screen or discover new drugs, and most importantly to supply an unlimited cell source for retinal regeneration