Publication: In vitro differentiation of primordial germ cells and oocyte-like cells from stem cells
Authors
Costa, José J.N. ; Souza, Glaucinete B. ; Soares, Maria A.A. ; Ribeiro, Regislane P. ; van den Hurk, Robert ; Silva, José R.V.
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-917
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info:eu-repo/semantics/article
Description
Abstract
Infertility is the result of failure due to an
organic disorder of the reproductive organs, especially
their gametes. Recently, much progress has been made
on generating germ cells, including oocytes, from
various types of stem cells. This review focuses on
advances in female germ cell differentiation from
different kinds of stem cells, with emphasis on
embryonic stem cells, adult stem cells, and induced
pluripotent stem cells. The advantages and
disadvantages of the derivation of female germ cells
from several types of stem cells are also highlighted, as
well as the ability of stem cells to generate mature and
functional female gametes. This review shows that stem
cell therapies have opened new frontiers in medicine,
especially in the reproductive area, with the possibility
of regenerating fertility.
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Citation
Histology and Histopathology, Vol.33, nº2, (2018)
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