Publication:
Patient iPSC-derived retinal organoids: Observable retinal diseases in-a-dish

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Zhang-36-705-710-2021.pdf(2.47 MB)
Date
2021
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Authors
Zhang, Xiao-Hui ; Jin, Zi-Bing
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-307
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info:eu-repo/semantics/article
Description
Abstract
Induced pluripotent stem cells (iPSCs), reprogrammed from human somatic cells, hold the capacity to differentiate into most human body cells. iPSCs can be differentiated into retinal organoids, a three-dimensional structured retina containing various retinal cells. Patient-specific retinal organoids provide a powerful disease model to recapitulate the disease to study the pathogenesis of inherited retinal dystrophies, to screen or discover new drugs, and most importantly to supply an unlimited cell source for retinal regeneration
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Induced pluripotent stem cells , Retinal organoids , Inherited retinal dystrophy , Gene editing , Disease modeling
Citation
Histology and Histopathology Vol. 36, nº7 (2021)
URI
http://hdl.handle.net/10201/127527
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Histology and histopathology Vol.36, nº7 (2021)
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