Publication: The MUC gene family, Their role in the diagnosis and prognosis of gastric cancer
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Date
2008
Authors
Senapati, Shantibhusan ; Sharma, Poonam ; Bafna, Sangeeta ; Roy, Hemant K. ; Batra, Surinder K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Early diagnosis of gastric cancer and its
differential diagnosis from other non-malignant gastric
diseases like gastritis is still a major clinical problem.
Most patients are asymptomatic in the early stages of
gastric cancer, and there is no reliable marker available
for the early and specific diagnosis of gastric cancer.
Many attempts have been made to define the biological
profile of gastric cancer to improve the chances of its
early diagnosis, prognosis and treatment. Several studies
have shown the aberrant expression profile of mucins in
different malignancies, suggesting that mucins have a
great potential to be used as a diagnostic and prognostic
marker in gastric cancer. In this review, we have briefly
described the different types of gastric adenocarcinomas
and the progression of gastric cancer. Furthermore, the
role of mucins and their related carbohydrate epitope is
discussed in the normal stomach and in the diagnosis
and prognosis of gastric adenocarcinomas.
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