Publication: Scanning electron microscopy
of capsaicin-pretreated trachea in
the rat during postnatal developrnent
Authors
Yu, S. M. ; Lin, K. H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The morphological changes of the tracheal
surface were studied in neonatally capsaicin-pretreated
rats by scanning electron microscopy. One week after
neonatal capsaicin treatment, a sparse number of ciliated
cells were dispersed among the microvilli-covered
goblet cells similar to those of the sham-operated rats.
Potential ciliated cells (progenitor cells) possessed a few
long cilia and many short cilia. The ciliated cells
possessed cilia with a smooth surface and a blunt end
similar to that of the sham-operated rats. Two weeks
after neonatal capsaicin treatment, numerous ciliated
cells frequently in clusters were located among large
patches of microvilli-covered goblet cells similar to
those of sham-operated rats. Furthermore, the blunt ends
of cilia and microvilli contained short star-shaped
protrusions extending into the lumen of the trachea. One
month after neonatal capsaicin treatment, the star-shaped
protrusions became longer, and more irregular than those
of sham-operated rats. The short cilia of the potential
ciliated cells (progenitor cells) also became blunt and
irregular in shape. The star-shaped protrusions of the
microvilli of the goblet cells became larger and thicker
than those observed at two weeks following capsaicinpretreatment.
Two months after neonatal capsaicin
treatment, the tracheal surface was lined with a much
greater population of the ciliated cells than that at one
month. A striking characteristic at this age was that
globular mucin-containing secretory products were
trapped within the cilia of the ciliated cells. The results
of this study suggest that mucus secretion is probably
blocked by the capsaicin-pretreatment. Furthermore, the
star-shaped protrusions of cilia and microvilli may
indicate that the mucociliary clearance mechanism is
interfered with by the capsaicin-pretreatment.
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