Publication: Neurotrophic keratopathy;
its pathophysiology and treatment
Authors
Okada, Yuka ; Reinach, Peter S. ; Kitano, Ai ; Shirai, Kumi ; Kao, Winston W.-Y. ; Saika, Shizuya
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Neurotropic keratopathy is one of the major
refractory corneal disorders, which was first recognized
in 1824. This category of diseases is caused by damage
to the trigeminal nerve and the consequent loss of
corneal sensation. It leads to various types of corneal
disorder, including superficial keratopathy, persistent
epithelial defects and corneal ulcers. In the present
article, we review the pathobiology and prevention/
treatment of neurotrophic corneal diseases.
The goals of treatment of neurotrophic keratopathy
are to prevent the progression of corneal damage to
promote epithelial healing in case that the original
damage in the trigeminal nerve or its braches is difficult.
The therapy should be prompt and based on the clinical
stage of the disease. Although at present, there are no
accurate treatment methods for neurotrophic
keratopathy, several effective treatments have been
reported.
Signals derived from TRP channels are involved in
homeostasis of tissues by controlling cell behaviors, i. e.,
gene expression for inflammation, cell migration, or cell
survival/cell death. Targeting TRP channel in the cornea
is expected to contribute to the development of a new
treatment method for neurotrophic keratopathy. Further
study and clinical trial are need to establish this new
treatment strategy
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