Publication:
Influence of metal ion solutions on rabbit osteoclast activities in vitro

Simple item page
dc.contributor.authorRousselle, A.V.es
dc.contributor.authorHeymann, D.es
dc.contributor.authorDemais, V.
dc.contributor.authorCharrier, C.
dc.contributor.authorPassuti, N.
dc.contributor.authorBaslé, Michael-Félix
dc.date.accessioned2011-05-11T10:58:57Z
dc.date.available2011-05-11T10:58:57Z
dc.date.issued2002
dc.description.abstractThe purpose of the present study was to compare the effects of various metal ions (aluminium, chromium, cobalt, gold, iron, strontium, titanium and vanadium) on rabbit osteoclast activities, with respect to their number, size, resorptive capacity and their capacity to release proteinases. Marked heterogeneous osteoclastic behaviour was observed early in culture with metal ions (24 h) in term of resorption parameters. In contrast, protease activities (cysteine-proteinase and metalloproteinase activities) were not modulated in our culture conditions. Aluminium, iron, gold and titanium reduced the number of osteoclasts significantly. Aluminium and gold had no effect on osteoclastmediated resorption on dentin-slices, although aluminium induced a greater number of very small lacunae. Titanium reduced only the mean surface area per lacunae, cobalt reduced the mean surface area of lacunae and increased their number, and iron reduced both parameters. Strontium had no effect on osteoclast formation and on total dentin slice surface resorbed. However, strontium increased the number of small lacunae formed on dentin-slices by osteoclasts. Chromium had no effect on osteoclast activities. These findings indicate that metal ions induce very early effects on osteoclasts, which can contribute to periprosthetic pathologies via different cellular mechanisms.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20840
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectOsteoclastes
dc.subjectMetal ionses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleInfluence of metal ion solutions on rabbit osteoclast activities in vitroes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Influence of metal ion solutions.pdf
Size:
429.2 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.17, nº 4 (2002)