Publication: Influence of metal ion solutions on rabbit osteoclast activities in vitro
Authors
Rousselle, A.V. ; Heymann, D. ; Demais, V. ; Charrier, C. ; Passuti, N. ; Baslé, Michael-Félix
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The purpose of the present study was to
compare the effects of various metal ions (aluminium,
chromium, cobalt, gold, iron, strontium, titanium and
vanadium) on rabbit osteoclast activities, with respect to
their number, size, resorptive capacity and their capacity
to release proteinases. Marked heterogeneous
osteoclastic behaviour was observed early in culture
with metal ions (24 h) in term of resorption parameters.
In contrast, protease activities (cysteine-proteinase and
metalloproteinase activities) were not modulated in our
culture conditions. Aluminium, iron, gold and titanium
reduced the number of osteoclasts significantly.
Aluminium and gold had no effect on osteoclastmediated
resorption on dentin-slices, although
aluminium induced a greater number of very small
lacunae. Titanium reduced only the mean surface area
per lacunae, cobalt reduced the mean surface area of
lacunae and increased their number, and iron reduced
both parameters. Strontium had no effect on osteoclast
formation and on total dentin slice surface resorbed.
However, strontium increased the number of small
lacunae formed on dentin-slices by osteoclasts.
Chromium had no effect on osteoclast activities. These
findings indicate that metal ions induce very early
effects on osteoclasts, which can contribute to
periprosthetic pathologies via different cellular
mechanisms.
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