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Effects of Friend leukemia virus (FLV) inoculation in F1 mice and differentiation of FLV-induced leukemia

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dc.contributor.authorMasanobu Kitagawaes
dc.contributor.authorOsamu Matsubaraes
dc.contributor.authorTsutomu Kasuga
dc.date.accessioned2011-01-17T12:39:30Z
dc.date.available2011-01-17T12:39:30Z
dc.date.issued1986
dc.description.abstractEffects of Friend leukemia virus (FLV) inoculation in F, specific pathogen free (SPF) mice were examined. Resistance to FLV was dominantly inherited both in F, hybrid mice (BDF,) (FLV-resistant & FLVsensitive with polycythemia) and F, hybrid mice (B6C3FI) (FLV-resitant & FLV-sensitive with anemia). But the population dynamics of the nucleated cell components of F, mice after FLV inoculation differed from those of FLV-resistant inbred mice. A small number of mature erythroblasts appeared in the peripheral blood of BDF, mice. In B6C3FI mice, erythroblastosis with splenomegaly and polycythemia occurred. However, all of these findings in BDF, and B6C3FI mice regressed spontaneously. In F, mice, FLV induced an intermediate reactive pattern of the two patterns that had been induced in the parental strains. The results indicate that FLV may induce leukemia with various degrees of differentiation, according to the genetic difference of the host.
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/17840
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectRetrovirus infectiones
dc.subjectExperimental leukemiaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.1 - Patología del sistema circulatorio, de los vasos sanguíneos. Transtornos cardiovasculareses
dc.titleEffects of Friend leukemia virus (FLV) inoculation in F1 mice and differentiation of FLV-induced leukemiaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 1, nº 4 (1986)