Publication: Effects of Friend leukemia virus (FLV) inoculation in F1 mice and differentiation of FLV-induced leukemia
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Date
1986
Authors
Masanobu Kitagawa ; Osamu Matsubara ; Tsutomu Kasuga
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Effects of Friend leukemia virus (FLV)
inoculation in F, specific pathogen free (SPF) mice were
examined. Resistance to FLV was dominantly inherited
both in F, hybrid mice (BDF,) (FLV-resistant & FLVsensitive
with polycythemia) and F, hybrid mice (B6C3FI)
(FLV-resitant & FLV-sensitive with anemia). But the
population dynamics of the nucleated cell components of
F, mice after FLV inoculation differed from those of
FLV-resistant inbred mice. A small number of mature
erythroblasts appeared in the peripheral blood of BDF,
mice. In B6C3FI mice, erythroblastosis with splenomegaly
and polycythemia occurred. However, all of these findings
in BDF, and B6C3FI mice regressed spontaneously. In F,
mice, FLV induced an intermediate reactive pattern of the
two patterns that had been induced in the parental strains.
The results indicate that FLV may induce leukemia with
various degrees of differentiation, according to the genetic
difference of the host.
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