IL-8 expression in malignant melanoma: implications in growth and metastasis

Singh, R. K.; Varney, M. L.

Publication:
IL-8 expression in malignant melanoma: implications in growth and metastasis

dc.contributor.author	Singh, R. K.
dc.contributor.author	Varney, M. L.
dc.date.accessioned	2020-07-23T12:29:51Z
dc.date.available	2020-07-23T12:29:51Z
dc.date.issued	2000
dc.description.abstract	This review article has described briefly studies supporting the concept that IL-8 expression and its regulation by inflammatory cytokines like IL-l may play an important role in controlling the phenotypes associated with melanoma progression and metastasis. It is clear from the experiments presented here that IL-8 is an important autocrine multifunctional cytokine that modulates melanoma/cell proliferation, migration by induction of extracellular matrix degradation enzymes and induces neovascularization, all of which are critical for melanoma growth and metastasis. In addition, their expression in melanoma tumor specimens suggests an association between IL-8 expression and tumor aggressiveness. Further, inflammatory cytokines produced by either tumor cells or stromal cells may regulate IL-8 expression, which can control melanoma growth and enhance our current knowledge regarding melanoma progression and metastasis. U nderstandi ng these events and their significance will allow us to design novel therapeutic approaches for treatment of melanoma.	es
dc.format	application/pdf	es
dc.format.extent	7	es
dc.identifier.citation	Histology and Histopathology, Vol. 15, n.º 3 (2000)
dc.identifier.doi	0213-3911
dc.identifier.issn	1699-5848
dc.identifier.uri	http://hdl.handle.net/10201/95167
dc.language	eng	es
dc.publisher	F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	IL-8	es
dc.subject	Melanoma	es
dc.subject	Metastasis	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología	es
dc.title	IL-8 expression in malignant melanoma: implications in growth and metastasis	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es

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