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IL-8 expression in malignant melanoma: implications in growth and metastasis

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IL-8 expression in malignant melanoma, implications in growth and metastasis.pdf(5.1 MB)
Date
2000
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Authors
Singh, R. K. ; Varney, M. L.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
0213-3911
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info:eu-repo/semantics/article
Description
Abstract
This review article has described briefly studies supporting the concept that IL-8 expression and its regulation by inflammatory cytokines like IL-l may play an important role in controlling the phenotypes associated with melanoma progression and metastasis. It is clear from the experiments presented here that IL-8 is an important autocrine multifunctional cytokine that modulates melanoma/cell proliferation, migration by induction of extracellular matrix degradation enzymes and induces neovascularization, all of which are critical for melanoma growth and metastasis. In addition, their expression in melanoma tumor specimens suggests an association between IL-8 expression and tumor aggressiveness. Further, inflammatory cytokines produced by either tumor cells or stromal cells may regulate IL-8 expression, which can control melanoma growth and enhance our current knowledge regarding melanoma progression and metastasis. U nderstandi ng these events and their significance will allow us to design novel therapeutic approaches for treatment of melanoma.
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IL-8 , Melanoma , Metastasis
Citation
Histology and Histopathology, Vol. 15, n.º 3 (2000)
URI
http://hdl.handle.net/10201/95167
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Histology and histopathology Vol.15, nº 3 (2000)
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