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Demineralized bone matrix coating Si-Ca-P Ceramic does not improve the osseointegration of the scaffold

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dc.contributor.authorParrilla-Almansa, Andrés
dc.contributor.authorGarcía Carrillo, Nuria
dc.contributor.authorRos-Tárraga, Patricia
dc.contributor.authorMartínez, Carlos Manuel
dc.contributor.authorMartínez Martínez, Francisco
dc.contributor.authorMeseguer Olmo, Luis
dc.contributor.authorDe Aza, Piedad N.
dc.contributor.departmentCirugía, Pediatría y Obstetricia y Ginecología
dc.date.accessioned2025-05-08T11:14:35Z
dc.date.available2025-05-08T11:14:35Z
dc.date.issued2018-09-01
dc.description© 2018 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Materials. To access the final edited and published work see https://doi.org/10.3390/ma11091580
dc.description.abstractThe aim of this study was to manufacture and evaluate the effect of a biphasic calcium silicophosphate (CSP) scaffold ceramic, coated with a natural demineralized bone matrix (DBM), to evaluate the efficiency of this novel ceramic material in bone regeneration. The DBM-coated CSP ceramic was made by coating a CSP scaffold with gel DBM, produced by the partial sintering of different-sized porous granules. These scaffolds were used to reconstruct defects in rabbit tibiae, where CSP scaffolds acted as the control material. Micro-CT and histological analyses were performed to evaluate new bone formation at 1, 3, and 5 months post-surgery. The present research results showed a correlation among the data obtained by micro-CT and the histomorphological results, the gradual disintegration of the biomaterial, and the presence of free scaffold fragments dispersed inside the medullary cavity occupied by hematopoietic bone marrow over the 5-month study period. No difference was found between the DBM-coated and uncoated implants. The new bone tissue inside the implants increased with implantation time. Slightly less new bone formation was observed in the DBM-coated samples, but it was not statistically significant. Both the DBM-coated and the CSP scaffolds gave excellent bone tissue responses and good osteoconductivity.es
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dc.format.extent16es
dc.identifier.citationMaterials 2018, 11(9), 1580
dc.identifier.doihttps://doi.org/10.3390/ma11091580
dc.identifier.issn1996-1944
dc.identifier.urihttp://hdl.handle.net/10201/154297
dc.languageenges
dc.publisherMDPI
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://www.mdpi.com/1996-1944/11/9/1580
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDicalcium silicatees
dc.subjectTricalcium phosphatees
dc.subjectDemineralized bone matrixes
dc.subjectBone regenerationes
dc.subjectMicro-CTes
dc.subjectHistomorphometryes
dc.titleDemineralized bone matrix coating Si-Ca-P Ceramic does not improve the osseointegration of the scaffoldes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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