Publication: Demineralized bone matrix coating Si-Ca-P Ceramic does not improve the osseointegration of the scaffold
Authors
Parrilla-Almansa, Andrés ; García Carrillo, Nuria ; Ros-Tárraga, Patricia ; Martínez, Carlos Manuel ; Martínez Martínez, Francisco ; Meseguer Olmo, Luis ; De Aza, Piedad N.
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Publisher
MDPI
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DOI
https://doi.org/10.3390/ma11091580
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info:eu-repo/semantics/article
Description
© 2018 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Materials. To access the final edited and published work see https://doi.org/10.3390/ma11091580
Abstract
The aim of this study was to manufacture and evaluate the effect of a biphasic calcium silicophosphate (CSP) scaffold ceramic, coated with a natural demineralized bone matrix (DBM), to evaluate the efficiency of this novel ceramic material in bone regeneration. The DBM-coated CSP ceramic was made by coating a CSP scaffold with gel DBM, produced by the partial sintering of different-sized porous granules. These scaffolds were used to reconstruct defects in rabbit tibiae, where CSP scaffolds acted as the control material. Micro-CT and histological analyses were performed to evaluate new bone formation at 1, 3, and 5 months post-surgery. The present research results showed a correlation among the data obtained by micro-CT and the histomorphological results, the gradual disintegration of the biomaterial, and the presence of free scaffold fragments dispersed inside the medullary cavity occupied by hematopoietic bone marrow over the 5-month study period. No difference was found between the DBM-coated and uncoated implants. The new bone tissue inside the implants increased with implantation time. Slightly less new bone formation was observed in the DBM-coated samples, but it was not statistically significant. Both the DBM-coated and the CSP scaffolds gave excellent bone tissue responses and good osteoconductivity.
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Citation
Materials 2018, 11(9), 1580
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