Publication: Expression, localization and function of
galectin-8, a tandem-repeat lectin, in human tumors
Authors
Elola, María T. ; Ferragut, Fátima ; Cárdenas Delgado, Víctor M. ; Nugnes, Lorena G. ; Gentilini, Lucas ; Laderach, Diego ; Troncoso, María F. ; Compagno, Daniel ; Wolfenstein-Tode, Carlota ; Rabinovich, Gabriel A.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Galectin-8 (Gal-8) is a ‘tandem-repeat’-type
galectin, which possesses two carbohydrate recognition
domains connected by a linker peptide. Gal-8
complexity is related to the alternative splicing of its
mRNA precursor, which is known to generate isoforms.
Regarding its carbohydrate-binding specificity, Gal-8
has a unique feature among galectins, since its Cterminal
domain has higher affinity for N-glycan-type
branched oligosaccharides, while its N-terminal domain
shows strong affinity for α2-3-sialylated or 3’-sulfated
ß-galactosides. We integrate here the available
information on Gal-8 expression in different tumor types
and attempt to elucidate associations of its expression
and localization during tumor progression with the
overarching goal of analyzing its potential applications
in diagnosis and prognosis. Differential diagnosis is still
a prime concern in tumor pathology, and Gal-8 could be
of great value in some types of primary or secondary
tumors (i.e. papillary thyroid carcinoma, advanced colon
carcinoma from patients with distant metastases, or
metastases from primary lung carcinoma). The
prognostic value of Gal-8 has been described for
laryngeal carcinoma as well as advanced colon
carcinoma. Further studies are needed to explain the
relevance of Gal-8 and its isoforms in tumor pathology
and their different intra- or extracellular roles
(cytoplasmic, nuclear or extracellular) in tumor biology.
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Citation
Histology and Histopathology, vol. 29, nº 9, (2014)
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