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Neurotrophin and Trk receptor-like immunoreactivity in the frog gastrointestinal tract

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dc.contributor.authorMaruccio, L.es
dc.contributor.authorCastaldo, L.es
dc.contributor.authorDe Girolamo, P.
dc.contributor.authorLucini, C.
dc.date.accessioned2011-06-08T09:08:11Z
dc.date.available2011-06-08T09:08:11Z
dc.date.issued2004
dc.description.abstractNerve growth factor (NGF), brain derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are members of the neurotrophin family, which is involved in the differentiation, growth, repair, plasticity and maintenance of many neuronal populations. They act through three tyrosin-kinase (Trk) specific receptors: NGF bind to TrkA, BDNF to TrkB and NT3 to TrkC. Despite increasing evidence regarding the presence of neurotrophin and their receptors in many vertebrate species, in amphibians there are very few data concerning them. Thus, the aim of this study was to extend the investigation to the presence of both neurotrophins and their Trk receptors in the gut of an anuran amphibian, Rana temporaria. In the frog gut NT-3- like immunoreactivity (IR) was observed in both the nervous system and endocrine cells of the stomach and intestine, while NGF-like IR was observed only in the enteric nervous system, and BDNFlike IR in the intestinal endocrine cells. TrkA- and TrkBlike IR was detected in both neurons and endocrine cells of the intestine, while TrkC-like IR was observed only in intestinal neurons. No Trk IR was detected in the stomach. The occurrence of the IR to neurotrophins and their receptors in the gut of the frog further confirms the wellconserved presence of this family of growth factors and Trk receptors during the evolution of vertebrates and suggests their complex involvement in the biology of the gastrointestinal neuro-endocrine system.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21550
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyen_EN
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectAmphibiansen_EN
dc.subjectNeurotrophin receptorsen_EN
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleNeurotrophin and Trk receptor-like immunoreactivity in the frog gastrointestinal tracten_EN
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.19, nº 2 (2004)