Publication: Neurotrophin and Trk receptor-like
immunoreactivity in the frog gastrointestinal tract
Authors
Maruccio, L. ; Castaldo, L. ; De Girolamo, P. ; Lucini, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Nerve growth factor (NGF), brain derived
neurotrophic factor (BDNF) and neurotrophin-3 (NT-3)
are members of the neurotrophin family, which is
involved in the differentiation, growth, repair, plasticity
and maintenance of many neuronal populations. They
act through three tyrosin-kinase (Trk) specific receptors:
NGF bind to TrkA, BDNF to TrkB and NT3 to TrkC.
Despite increasing evidence regarding the presence
of neurotrophin and their receptors in many vertebrate
species, in amphibians there are very few data
concerning them. Thus, the aim of this study was to
extend the investigation to the presence of both
neurotrophins and their Trk receptors in the gut of an
anuran amphibian, Rana temporaria.
In the frog gut NT-3- like immunoreactivity (IR) was
observed in both the nervous system and endocrine cells
of the stomach and intestine, while NGF-like IR was
observed only in the enteric nervous system, and BDNFlike
IR in the intestinal endocrine cells. TrkA- and TrkBlike
IR was detected in both neurons and endocrine cells
of the intestine, while TrkC-like IR was observed only in
intestinal neurons. No Trk IR was detected in the
stomach.
The occurrence of the IR to neurotrophins and their
receptors in the gut of the frog further confirms the wellconserved
presence of this family of growth factors and
Trk receptors during the evolution of vertebrates and
suggests their complex involvement in the biology of the
gastrointestinal neuro-endocrine system.
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