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Phenotypic characterization of hereditary epithelial ovarian cancer based on a tissue microarray study

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dc.contributor.authorMuñoz-Repeto, Iván
dc.contributor.authorGarcía, María José
dc.contributor.authorKamieniak, María
dc.contributor.authorRamón y Cajal, Teresa
dc.contributor.authorDomingo, Samuel
dc.contributor.authorCazorla, Cazorla
dc.contributor.authorGarcía Donas, Jesús
dc.contributor.authorHernando Polo, Susana
dc.contributor.authorGarcía Sagredo, José Miguel
dc.contributor.authorHernández, Elena
dc.contributor.authorLacambra, Carmen
dc.contributor.authorSáez, Raquel
dc.contributor.authorRobles, Luis
dc.contributor.authorBorrego, Salud
dc.contributor.authorPrat, Jaime
dc.contributor.authorPalacios, José
dc.contributor.authorBenítez, Javier
dc.date.accessioned2018-02-13T18:36:21Z
dc.date.available2018-02-13T18:36:21Z
dc.date.issued2013
dc.description.abstractThe pathologic and immunohistochemical features of familial epithelial ovarian cancers are not well understood. We have carried out a comprehensive immunohistochemical study of familial ovarian carcinomas from women with and without BRCA1 or BRCA2 mutations, in order to identify specific and/or common features among these different familial case groups (BRCA1, BRCA2 and non-BRCA1/2) and to identify markers of diagnostic value that might help to select more specific treatments. 73 familial primary ovarian carcinomas were analyzed for the expression of 40 antibodies involved in different genetic pathways using a tissue microarray. Serous carcinomas comprised the majority of all three familial case groups. On the other hand, BRCA1 and BRCA2 carcinomas have similar histopathologic features; i.e. they are often highgrade and are usually diagnosed at a more advanced FIGO stage than non-BRCA1/2 carcinomas. In our series, BRCA1 carcinomas had better clinical evolution and they also more frequently over-expressed PR and P53 than BRCA2 and non-BRCA1/2carcinomas. Unsupervised cluster analysis and survival analysis identified ERCC1 as a potential marker of better clinical outcome for hereditary epithelial ovarian cancer.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and histopathology, Vol. 28, n.º 1 (2013)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/56105
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectHereditaryes
dc.subjectEpithelial ovarian canceres
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::618 - Ginecología. Obstetriciaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titlePhenotypic characterization of hereditary epithelial ovarian cancer based on a tissue microarray studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.28, nº 1 (2013)