Publication: Phenotypic characterization of hereditary epithelial ovarian cancer based on a tissue microarray study
Authors
Muñoz-Repeto, Iván ; García, María José ; Kamieniak, María ; Ramón y Cajal, Teresa ; Domingo, Samuel ; Cazorla, Cazorla ; García Donas, Jesús ; Hernando Polo, Susana ; García Sagredo, José Miguel ; Hernández, Elena ; Lacambra, Carmen ; Sáez, Raquel ; Robles, Luis ; Borrego, Salud ; Prat, Jaime ; Palacios, José ; Benítez, Javier
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The pathologic and immunohistochemical
features of familial epithelial ovarian cancers are not
well understood. We have carried out a comprehensive
immunohistochemical study of familial ovarian
carcinomas from women with and without BRCA1 or
BRCA2 mutations, in order to identify specific and/or
common features among these different familial case
groups (BRCA1, BRCA2 and non-BRCA1/2) and to
identify markers of diagnostic value that might help to
select more specific treatments. 73 familial primary
ovarian carcinomas were analyzed for the expression of
40 antibodies involved in different genetic pathways
using a tissue microarray. Serous carcinomas comprised
the majority of all three familial case groups. On the
other hand, BRCA1 and BRCA2 carcinomas have
similar histopathologic features; i.e. they are often highgrade
and are usually diagnosed at a more advanced
FIGO stage than non-BRCA1/2 carcinomas. In our
series, BRCA1 carcinomas had better clinical evolution
and they also more frequently over-expressed PR and
P53 than BRCA2 and non-BRCA1/2carcinomas.
Unsupervised cluster analysis and survival analysis
identified ERCC1 as a potential marker of better clinical
outcome for hereditary epithelial ovarian cancer.
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Citation
Histology and histopathology, Vol. 28, n.º 1 (2013)
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