Publication: Neuronal and mixed neuronal glial tumors associated to epilepsy. A heterogeneous and related group of tumours
Authors
Moreno, A. ; Felipe, J.de ; García Sola, R. ; Navarro, A. ; Ramón y Cajal, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The group of brain tumors with mature
components encompasses severa1 pathological entities
including: the ganglioneuroma; the gangliocytoma; the
ganglioglioma; the desmoplastic ganglioglioma; the
neurocitoma and a group of glioneuronal hamartomatous
tumorous lesions, such as meningoangiomatosis. The
dysembryoplastic neuroepithelial tumor is characterized
by the presence of multiple cortical nodules made up of
small, oligo-like cells and a myxoid pattern rich in
mucopolysaccharides. Mature neuronal cells are
frequently detected throughout the tumor. Most of them
are associated with microhamartias in the adjacent brain
and pharmacoresistant epilepsy. The excellent prognosis
of the majority of these tumors and the potential for
malignant transformation of the glial component in the
ganglioglioma are the two most remarkable findings.
Histological signs of anaplasia and greater mitotic and
proliferative activities are associated with local
recurrences. Atypical neurocytomas occur only
exceptionally. Treatment choices are surgical
resectioning and, in those cases presenting greater
proliferative activity and cytological atypia,
postoperative radiotherapy rnay be recornmended.
This paper reviews this heterogeneous group of
neoplasms and hamartomatous lesions, pointing out
presumable transitions among the different types of
mixed neuronal and glial brain tumors. A single term of "mixed neuronal-glial tumors" is defended,
distinguishing different subgroups of tumors, depending
on the predominant cellular component.
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