Publication: Hormonal receptors, cell proliferation fraction Ki-67 and c-erbB-2 amplification in breast cancer. Relationship between differentiation degree and ...
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Date
1994
Authors
Sirvent, J.J. ; Santafe, M. ; Salvadó, M.T. ; Alvaro, T. ; Raventos, A. ; Palacios, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In view of the limitations of conventional
prognostic factors such as differentiation degree,
metastatic lymph nodes, hormonal receptors and others,
especially when early lesions are found, additional new
markers have been studied, such as gene amplification
and cell proliferation index, in order to choose the appropriate
treatment. Primary breast carcinoma tumors from
97 patients were examined for differentiation degree,
metastatic lymph nodes, hormonal receptors, c-erbB-2
amplification and cell proliferation index (Ki-67).
A negative relationship with hormonal receptors and
c-erbB-2 amplification, Ki-67 and differentiation degree
was found, whereas the relationship between c-erb13-2,
Ki-67 and differentiation degree was positive.
No relationship was found between these factors and
metastatic lymph nodes.
The concurrence of high cell proliferation index, cerbB-
2 amplification and negative hormonal receptor
presence would indicate a subpopulation with a high risk
of recurrence. But a larger survival study is necessary to
correlate these factors with clinical outcome.
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