Publication:
The effects of Eicosapentaenoic acid on the endothelium of the carotid artery of rabbits on a high-cholesterol diet

Simple item page
dc.contributor.authorCayli, Seviles
dc.contributor.authorSati, Leylaes
dc.contributor.authorSeval-Celik, Yasemin
dc.contributor.authorAltug Tuncer, M.
dc.contributor.authorYaymaci, Bengi
dc.contributor.authorBerkman, Zafer
dc.contributor.authorAltug, Tuncay
dc.contributor.authorDemir, Ramazan
dc.date.accessioned2015-01-20T12:06:08Z
dc.date.available2015-01-20T12:06:08Z
dc.date.issued2010
dc.description.abstractThe preventive and therapeutic effects ofEicosapentaenoic acid (EPA) on diet-inducedhyperlipidemia in rabbits have been investigated.Eighteen New Zealand rabbits were randomly dividedinto three groups of 6 subjects each; experimental group-I (EG-I) was administered a cholesterol rich diet,experimental group-II (EG-II) was treated with EPA(300 mg/kg/d) following a cholesterol-rich diet and thecontrol group (CG) had a standard diet. Blood sampleswere collected at day 0 and at the 4th and 12th weeks ofEG-II to obtain serum levels of total cholesterol (TC),high density lipid-cholesterol (HDL-C), low densitylipid-cholesterol (LDL-C) and triglyceride (TG). Fromeach group tissue samples were collected from thecarotid artery for immunohistochemistry and electronmicroscopy. Our results showed that EPA couldsignificantly lower (p<0.001) serum TC, LDL-C, HDL-C and TG levels with a reduction of 35%; 55%; 44% and51%, respectively. Scanning and transmission electronmicroscopy results revealed that endothelial damage wasmore prominent in EG-I when compared to EG-II. Theruptured endothelial lining and damaged cellular surfacewas increased in EG-I when compared to EG-II.Ultrastructural observations showed that after EPAtreatment, the degeneration and cellular surface damageon the endothelium were also decreased. These biochemical and ultrastructural results suggestthat EPA is a potential drug which significantly lowersthe serum lipid profile and partially repairs endothelialdysfunction due to hyperlipidemiaen_EN
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/42579
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCholesteroles
dc.subjectAtherosclerosises
dc.subjectRabbit
dc.subject.other61 - Medicinaes
dc.titleThe effects of Eicosapentaenoic acid on the endothelium of the carotid artery of rabbits on a high-cholesterol dietes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
The effects of Eicosapentaenoic acid on the endothelium of the carotid artery of rabbits on a highcholesterol diet.pdf
Size:
5.42 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.25, nº2 (2010)