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Foreign serum-induced bile duct lesion BDL in athymic BALBIc nude mice

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dc.contributor.authorHonjo, K.es
dc.contributor.authorDoi, K.es
dc.date.accessioned2011-02-22T11:21:16Z
dc.date.available2011-02-22T11:21:16Z
dc.date.issued2000
dc.description.abstractTo investigate a role of cellular immunity in foreign serum-induced bile duct lesion (BDL) in mice, athymic BALB/c nude (nu/nu) mice were intraperitoneally injected with swine serum (SS) twice a week up to 8 weeks and were compared with euthymic BALB/c heterozygote (nu/+) and wild-type (+/+) mice treated with SS in the same way for 4 weeks. All immunized nu/+ and +/+ mice developed marked BDL, and their sera showed high anti-SS IgE and IgGl antibody titers, whereas no immunized nulnu mice developed lesions, and their sera showed no elevation of antibody titers. Next, nu/nu mice were reconstituted with splenocytes derived from nu/+ mice, and then were intraperitoneally injected with SS twice a week for 3 weeks. Most of the reconstituted nulnu mice developed BDL, and their sera showed the elevation of anti-SS IgE and IgG antibody titers. These results suggest that cellular immunity may play a pivotal role in the pathogenesis of swine serum-induced BDL.es
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19305
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCellular immunityes
dc.subjectForeign serumes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleForeign serum-induced bile duct lesion BDL in athymic BALBIc nude micees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.15, nº 2 (2000)