Publication: Foreign serum-induced bile duct lesion BDL in athymic BALBIc nude mice
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Date
2000
Authors
Honjo, K. ; Doi, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
To investigate a role of cellular immunity in
foreign serum-induced bile duct lesion (BDL) in mice,
athymic BALB/c nude (nu/nu) mice were intraperitoneally
injected with swine serum (SS) twice a
week up to 8 weeks and were compared with euthymic
BALB/c heterozygote (nu/+) and wild-type (+/+) mice
treated with SS in the same way for 4 weeks. All
immunized nu/+ and +/+ mice developed marked BDL,
and their sera showed high anti-SS IgE and IgGl
antibody titers, whereas no immunized nulnu mice
developed lesions, and their sera showed no elevation of
antibody titers. Next, nu/nu mice were reconstituted with
splenocytes derived from nu/+ mice, and then were
intraperitoneally injected with SS twice a week for 3
weeks. Most of the reconstituted nulnu mice developed
BDL, and their sera showed the elevation of anti-SS IgE
and IgG antibody titers. These results suggest that
cellular immunity may play a pivotal role in the
pathogenesis of swine serum-induced BDL.
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