Publication: Neurobiological toxicity of radiation in hippocampal cells
Authors
Kim, Joong-Sun ; Yang, Miyoung ; Kim, Sung-Ho ; Shin, Taekyun ; Moon, Changjong
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Publisher
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Worldwide radiation exposure is increasing
due to recent nuclear accidents, space travel, atomic
weapons testing and use, and medical treatments. In
adult animals, ionizing radiation can significantly impact
hippocampal neurogenesis and negatively affect
hippocampal functions such as cognition. However,
there is considerable uncertainty regarding the
mechanisms underlying these effects. This article
reviews in vivo and in vitro studies on the effects of
irradiation on hippocampal neurogenesis and function in
order to gain new mechanistic insights. This information
will provide complementary views of our understanding
of the normal brain’s tolerance to radiation exposure, the
potentially serious implications of radiation exposure to
cognition, and lead to a discussion of potential strategies
for pharmacotherapy and behavioral intervention.
Citation
Histology and histopathology, Vol. 28, n.Âş 3 (2013)
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