Publication: Ischemic tissue injury and progenitor cell tropism: significant contributors to the pathogenesis of pterygium
Authors
Kim, Kyoung Woo ; Ha, Hyo Shin ; Kim, Jae Chan
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-30.311
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info:eu-repo/semantics/article
Description
Abstract
Pterygium is a common ocular surface
disease characterized by triangular wing-like growth
consisting of subconjunctival hypertrophic connective
tissue. Pterygium is easily complicated by adhesion to
the eyelid and diplopia related to motility restriction of
the eyeball. Beyond the cosmetic problems, this
condition has a catastrophic effect on quality of life.
Post-surgical recurrence rates of pterygium excision
have been reported to be very high. Therefore,
identifying the distinct pathogenic pathways of the
disease may lead to new therapeutic strategies with
lower risk of treatment failure. Based on the relatively
low vascularity and known-predominance of disease
occurrence in the nasal conjunctiva of normal eyes, we
proposed that hypoxic ischemic injury can elicit the
development of pterygium. Here, we review hypoxiainducible factor (HIF)-1alpha-induced activation of the
stromal cell-derived factor-1 (SDF-1)/chemokine
receptor type 4 (CXCR4) signaling pathway as a
possible mechanism. Supporting this concept of
pathogenic mechanism, we also highlight bone marrowderived progenitor cell tropism as a main contributor to
pterygium pathogenesis.
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Citation
Histology and Histopathology, Vol. 30, n.º 3 (2015)
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