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Craniofacial morphology in Down syndrome: a systematic review and meta-analysis

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dc.contributor.authorVicente, Ascensión
dc.contributor.authorBravo-González, Luis-Alberto
dc.contributor.authorLópez-Romero, Ana
dc.contributor.authorSerna Muñoz, Clara
dc.contributor.authorSánchez-Meca, Julio
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned2024-01-25T17:08:17Z
dc.date.available2024-01-25T17:08:17Z
dc.date.issued2020
dc.descriptionMaterial submitted to Scientific Reports should not be discussed with the media, except in the case of accepted contributions, which can be discussed with the media once an embargo date has been set.es
dc.description.abstractThe aim of this study was to evaluate the craniofacial cephalometric characteristics of individuals with Down syndrome (DS), comparing them with healthy subjects. An electronic search was made in Pubmed, Embase, Lilacs, Scopus, Medline and Web of Science without imposing limitations on publication date or language. Studies were selecting following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. The PECO acronym was applied as follows: P (population), individuals with DS; E, (exposition) diagnosis of DS; C (comparison), individuals without DS; O (outcomes) craniofacial characteristics based on cephalometric measurements. Independent reviewers performed data extraction and assessed the methodological quality of the articles using the Newcastle–Ottawa Quality-Assessment-scale. Seven case–control studies were included in meta-analysis. Given the variability of the cephalometric measurements used, only those that had been reported in at least three or more works could be included. Anterior cranial base length (SN), posterior cranial base length (SBa), total cranial base length (BaN), effective length of the maxilla (CoA), sagittal relationship between subspinale and supramentale (ANB), anterior facial height (NMe), and posterior facial height (SGo) values were significantly lower in the DS population than among control subjects. No significant differences were found in sagittal position of subspinale relative to cranial base (SNA) and sagittal position of supramentale relative to cranial base (SNB). Summarizing, individuals with DS present a shorter and flatter cranial base than the general population, an upper jaw of reduced sagittal dimension, as well as a tendency toward prognatic profile, with the medium third of the face flattened and a reduced anterior and posterior facial heights.es
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dc.format.extent14es
dc.identifier.citationScientific Reports 10: 19895
dc.identifier.doihttps://doi.org/10.1038/s41598-020-76984-5
dc.identifier.urihttp://hdl.handle.net/10201/137805
dc.languageenges
dc.relationSin financiación externa a la Universidades
dc.rightsAttribution 4.0 International
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleCraniofacial morphology in Down syndrome: a systematic review and meta-analysises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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