Publication: Biomaterial scaffolds used for the
regeneration of spinal cord injury (SCI)
Authors
Kim, Moonhang ; Park, So Ra ; Choi, Byung Hyune
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
https://doi.org/10.14670/HH-29.1395
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info:eu-repo/semantics/article
Description
Abstract
This review presents a summary of various
types of scaffold biomaterials used alone or together
with therapeutic drugs and cells to regenerate spinal cord
injury (SCI). The inhibitory environment and loss of
axonal connections after SCI give rise to critical
obstacles to regeneration of lost tissues and neuronal
functions. Biomaterial scaffolds can provide a bridge to
connect lost tissues, an adhesion site for implanted or
host cells, and sustained release of therapeutic drugs in
the injured spinal cord. In addition, they not only
provide a structural platform, but can play active roles
by inhibiting apoptosis of cells, inflammation and scar
formation, and inducing neurogenesis, axonal growth
and angiogenesis. Many synthetic and natural
biomaterial scaffolds have been extensively investigated
and tested in vitro and in animal SCI models for these
purposes. We summarized the literature on the
biomaterials commonly used for spinal cord regeneration
in terms of historical backgrounds and current
approaches.
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Citation
Histology and Histopathology, Vol. 29, n.º 11 (2014)
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