Publication: Regulatory role of microRNAs in the proliferation
and differentiation of adipose-derived stem cells
Authors
Yeong Kim, Doo ; Sung, Jong Hyuk
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-798
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info:eu-repo/semantics/article
Description
Abstract
Adipose-derived stem cells (ASCs) are
multipotent mesenchymal stem cells obtained from
stromal-vascular fraction of adipose tissue. ASCs are a
promising resource for cell therapy due to their simple
isolation, extensive expansion potential, and low
immunogenicity. ASCs repair and regenerate damaged
tissue by direct differentiation, whereas many other
approaches rely on the secretion of paracrine factors.
miRNAs target mRNAs for cleavage or translational
repression, and have been shown to play critical roles in
the regulation of stem cell proliferation and
differentiation. The miRNA expression profile of ASCs
varies according to the isolation and culturing method,
and more than 40 different miRNAs have been reported
to regulate ASC proliferation and differentiation.
Therefore, this review summarizes the ASC-related
miRNAs and their pivotal roles in regulating the
proliferation and differentiation of ASCs. A
comprehensive understanding of the effects of miRNAs
on the proliferation and differentiation of ASCs is
important and useful to enhance the regenerative
potential of ASCs.
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Citation
Histology and Histopathology, Vol.32, nÂş1, (2017)
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