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Schwannomas, bening tumors with a senescent phenotype

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dc.contributor.authorSimonetti, S.
dc.contributor.authorSerrano, C.
dc.contributor.authorHernández-Losa, J.
dc.contributor.authorBagué, S.
dc.contributor.authorOrellana, R.
dc.contributor.authorValverde, C.
dc.contributor.authorLleonart, M. E.
dc.contributor.authorAizpurua, M.
dc.contributor.authorCarles, J.
dc.contributor.authorRamón y Cajal, S.
dc.contributor.authorRomagosa, C.
dc.date.accessioned2019-07-09T14:17:36Z
dc.date.available2019-07-09T14:17:36Z
dc.date.issued2014
dc.description.abstractBackground: Schwannomas are benign nerve sheath tumors that only very rarely undergo malignant changes. Oncogenic-induced senescence is a defense mechanism against such malignant transformation. Different molecular pathways are involved in this process, such as RAS-RAF-MAPK. Based on the fact that the RAS-RAF-MAPK pathway is known to be activated in peripheral nerve sheath tumors, this study analyzes senescence markers in Schwannomas to demonstrate the possible role of senescence in their genesis. Methods: A retrospective immunohistochemical study was done in 39 schwannoma and 18 malignant peripheral nerve sheath tumors (MPNST). Staining for p16INK4a, Ki67, p53 and CyclinD1 was performed in all the cases. Additionally, ß-galactosidase staining was done in those cases in which frozen tissue was available (n=8). Results: Higher levels of p16INK4a (p=0.0001) and lower levels of Ki67 (p=0.0001) were found in Schwannomas. Beta-galactosidase activity was positive in 5/5 Schwannomas and negative in 3/3 MPNST. Conclusions: Our results support the senescence nature of Schwannomas and the absence of a senescence phenotype in MPNST.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 6, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/73487
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectSchwannomases
dc.subjectMPNSTes
dc.subjectSenescencees
dc.subjectp16INK4aes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleSchwannomas, bening tumors with a senescent phenotypees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 6 (2014)