Publication: Schwannomas, bening tumors
with a senescent phenotype
Authors
Simonetti, S. ; Serrano, C. ; Hernández-Losa, J. ; Bagué, S. ; Orellana, R. ; Valverde, C. ; Lleonart, M. E. ; Aizpurua, M. ; Carles, J. ; Ramón y Cajal, S. ; Romagosa, C.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Background: Schwannomas are benign nerve
sheath tumors that only very rarely undergo malignant
changes. Oncogenic-induced senescence is a defense
mechanism against such malignant transformation.
Different molecular pathways are involved in this
process, such as RAS-RAF-MAPK. Based on the fact
that the RAS-RAF-MAPK pathway is known to be
activated in peripheral nerve sheath tumors, this study
analyzes senescence markers in Schwannomas to
demonstrate the possible role of senescence in their
genesis.
Methods: A retrospective immunohistochemical
study was done in 39 schwannoma and 18 malignant
peripheral nerve sheath tumors (MPNST). Staining for
p16INK4a, Ki67, p53 and CyclinD1 was performed in all
the cases. Additionally, ß-galactosidase staining was
done in those cases in which frozen tissue was available
(n=8).
Results: Higher levels of p16INK4a (p=0.0001) and
lower levels of Ki67 (p=0.0001) were found in
Schwannomas. Beta-galactosidase activity was positive
in 5/5 Schwannomas and negative in 3/3 MPNST.
Conclusions: Our results support the senescence
nature of Schwannomas and the absence of a senescence
phenotype in MPNST.
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Citation
Histology and Histopathology, vol. 29, nº 6, (2014)
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/