Publication: Involvement of autophagy in T cell biology
Authors
Oral, Ozlem ; Yedier, Ozlem ; Kilic, Seval ; Gozuacik, Devrim
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI:10.14670/HH-11-785
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info:eu-repo/semantics/article
Description
Abstract
Autophagy is an essential cellular pathway
that sequesters various cytoplasmic components,
including accumulated proteins, damaged organelles or
invading microorganisms and delivers them to
lysosomes for degradation. The function of autophagy
has been reported in various tissues and systems,
including its role in the regulation of cellular immunity.
Autophagy plays a fundamental role at various stages of
T cell maturation. It regulates the thymocyte selection
and the generation of T cell repertoire by presenting
intracellular antigens to MHC class molecules.
Autophagy is crucial for metabolic regulation of T cells,
and therefore supports cell survival and homeostasis,
particularly in activated mature T cells. Furthermore,
deletion of specific autophagy-related genes induces
several immunological alterations including
differentiation of activated T cells into regulatory,
memory or natural killer T cells. In this review, we
emphasize the impact of autophagy on T cell
development, activation and differentiation, which is
pivotal for the adaptive immune system.
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Citation
Histology and Histopathology, Vol.32, nÂş1, (2017)
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