Publication: Subchronic toxicity of 3,3',4,4'-tetrachlorobiphenyl in the rat liver. An electron microscope study
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Date
1994
Authors
MacLellan, K. ; Singhl, A. ; Chu, I. ; Villeneuve, David C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Ultrastructural effects of 3,3'4,4'-tetrachlorobiphenyl
(PCB) congener #77 on the liver were
evaluated following its feeding to Sprague-Dawley
weanling rats. Treatment diets were prepared by
dissolving the congener in 4% corn oil. Ten animals,
either male or female, in each group were placed on the
respective diets containing 10, 100, 1.000 and 10,000
ppb congener for 13 weeks. Ten animals of each sex
served as the control that had only the oil added to the
diets. In the congener-exposed animals the alterations
consisted of a marked increase in the profiles of smooth
endoplasmic reticulum, and in the heightened number of
lipid droplets in many parenchyma1 cells. Several
mitochondria showed abnormalities such as dumbbell
shapes, and in others, the cristae were oriented parallel
to the long axis of the organelle. Peroxisomes were
numerous in the 10 ppb group and apparently had
increased numerically in the liver of animals from the
higher dose groups. Females were notably more affected
by the congener when compared to their male
counterparts. The results indicated that the compound is
mildly toxic, and alteration in structure and function can
be noted at the lowest dose used (10 ppb congener
exposure). It is concluded that congener #77 may be
moderately toxic and it may affect the overall health of
the exposed animal.
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