Publication: Chromatin in embryonic stem cell neuronal differentiation
Authors
Meshorer, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Chromatin, the basic regulatory unit of the
eukaryotic genetic material, is controlled by epigenetic
mechanisms including histone modifications, histone
variants, DNA methylation and chromatin remodeling.
Cellular differentiation involves large changes in gene
expression concomitant with alterations in genome
organization and chromatin structure. Such changes are
particularly evident in self-renewing pluripotent
embryonic stem cells, which begin, in terms of cell fate,
as a tabula rasa, and through the process of
differentiation, acquire distinct identities. Here I describe
the changes in chromatin that accompany neuronal
differentiation, particularly of embryonic stem cells, and
discuss how chromatin serves as the master regulator of
cellular destiny.
Citation
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