Perspectives in gene therapy

Martín Duque, Mª del P.; Sánchez Prieto, R.; Lleonart, M.; Ramón y Cajal, S.

Publication:
Perspectives in gene therapy

dc.contributor.author	Martín Duque, Mª del P.
dc.contributor.author	Sánchez Prieto, R.
dc.contributor.author	Lleonart, M.
dc.contributor.author	Ramón y Cajal, S.
dc.date.accessioned	2020-05-22T14:03:00Z
dc.date.available	2020-05-22T14:03:00Z
dc.date.issued	1998
dc.description.abstract	Gene therapy is understood to be both the restitution of genetic alterations caused by mutation or deletion and the control of overexpressed genes. The concept of gene therapy can also encompass molecular strategies to induce cell death in tumor cell by either the so-called "suicided genes" or by certain viral genes that induce a more selective cell dea th among th e transformed cells. The prospect for the clinical application of gene therapy are enormous and, at least theoretically. its utilization can be extended to a number of diseases known to have a genetic basis, and to neoplastic processes. This review summarizes some of the projects that are currently underway involving neopla stic dise ases. liver disease s, hematopoi e tic cells and respiratory tract cells. The results of most of the ongoing protocols are not yet conclusive, and presumibly, their clinical application is still some years away. One of the major limitations is the method of introducing the ge ne tic sequences into the cells and achieving their constitutive expression by the cells. For ethical reasons, this approach should not be done in germ cells, but at the leve l of the tissue or cells most closely involved in the deve lopment of each gene-based disease. The methods employed in gene therapy are discussed, focusing on those med iated by the application of viral vectors, as well as those requiring the use of liposomes and others.	es
dc.format	application/pdf	es
dc.format.extent	12	es
dc.identifier.citation	Histology and histopathology, Vol. 13, nº 1 (1998)
dc.identifier.issn	1699-5848
dc.identifier.issn	0213-3911
dc.identifier.uri	http://hdl.handle.net/10201/92544
dc.language	eng	es
dc.publisher	F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Gene therapy	es
dc.subject	Viral vectors	es
dc.subject	Non -viral vectors	es
dc.subject.other	CDU::6 - Ciencias aplicadas::61 - Medicina	es
dc.title	Perspectives in gene therapy	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es