Publication:
Perspectives in gene therapy

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Perspectives in gene therapy.pdf(7.42 MB)
Date
1998
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Authors
Martín Duque, Mª del P. ; Sánchez Prieto, R. ; Lleonart, M. ; Ramón y Cajal, S.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Gene therapy is understood to be both the restitution of genetic alterations caused by mutation or deletion and the control of overexpressed genes. The concept of gene therapy can also encompass molecular strategies to induce cell death in tumor cell by either the so-called "suicided genes" or by certain viral genes that induce a more selective cell dea th among th e transformed cells. The prospect for the clinical application of gene therapy are enormous and, at least theoretically. its utilization can be extended to a number of diseases known to have a genetic basis, and to neoplastic processes. This review summarizes some of the projects that are currently underway involving neopla stic dise ases. liver disease s, hematopoi e tic cells and respiratory tract cells. The results of most of the ongoing protocols are not yet conclusive, and presumibly, their clinical application is still some years away. One of the major limitations is the method of introducing the ge ne tic sequences into the cells and achieving their constitutive expression by the cells. For ethical reasons, this approach should not be done in germ cells, but at the leve l of the tissue or cells most closely involved in the deve lopment of each gene-based disease. The methods employed in gene therapy are discussed, focusing on those med iated by the application of viral vectors, as well as those requiring the use of liposomes and others.
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Gene therapy , Viral vectors , Non -viral vectors
Citation
Histology and histopathology, Vol. 13, nº 1 (1998)
URI
http://hdl.handle.net/10201/92544
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Histology and histopathology Vol.13, nº 1 (1998)
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