Publication: Salivary adiponectin, but not adenosine deaminase, correlates with clinical signs in women with Sjögren's syndrome: a pilot study
Authors
López Jornet, María Pía ; Tvarijonaviciute, Asta ; Zamora, Carmen ; Martinez Subiela, Silvia ; Tecles, Fernando ; Pina, Francisca
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Publisher
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DOI
10.1007/s00784-018-2570-3
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info:eu-repo/semantics/article
Description
Abstract
Abstract
Objectives: To evaluate salivary adiponectin and adenosine deaminase (ADA) in women suffering from Sjögren's syndrome (SS).
Methods: Salivary adiponectin and ADA were measured in patients with SS (n = 17) and compared to their values in healthy controls (n = 13) and patients suffering from drug-induced xerostomia (non-SS sicca group; n = 19). A clinical history was made for each patient, patients were examined clinically, and xerostomia inventory (XI) was performed.
Results: Salivary adiponectin corrected by total protein was higher in patients with SS than in healthy individuals (P < 0.05) or patients with non-SS sicca (P < 0.01) and correlated with XI (r = 0.555; P < 0.05). Salivary ADA was higher in patients with SS and non-SS sicca compared to controls (P < 0.05 in both cases).
Conclusion: The results of the present study indicate that adiponectin and ADA are increased in the saliva of patients with SS.
Clinical relevance: Salivary adiponectin corrected by total protein can be a potential biomarker of SS.
Trial registration: NCT03156569.
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Citation
Clinical Oral Investigations
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