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The use of human sterilized crushed tooth particles compared with BTCP biomaterial and empty defects in bone formation inside critical rabbit calvaria sites

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dc.contributor.authorCalvo Guirado, José Luis
dc.contributor.authorCabo Pastor, Marta Belén
dc.contributor.authorMartínez Martínez, Francisco
dc.contributor.authorGarcés Villalá, Miguel Ángel
dc.contributor.authorCarlos Villafranca, Félix de
dc.contributor.authorGarcía Carrillo, Nuria
dc.contributor.authorFernández Domínguez, Manuel
dc.contributor.departmentCirugía, Pediatría y Obstetricia y Ginecología
dc.date.accessioned2025-05-08T10:52:02Z
dc.date.available2025-05-08T10:52:02Z
dc.date.issued2023-05-24
dc.description© 2023 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Published Manuscript version of a Published Work that appeared in final form in Bioengineering. To access the final edited and published work see https://doi.org/10.3390/bioengineering10060638
dc.description.abstractThis study aimed to assess the bone regeneration of critical-size defects in rabbit calvaria filled with freshly crushed extracted teeth, comparing them with BTCP biomaterial and empty sites. Materials and methods: Twenty-one female New Zealand rabbits were used in this study. Two critical-size defects 6 mm in size were created in the skull bone, each with a 3 mm separation between them. Three experimental groups were evaluated: Group A (human sterilized crushed teeth granules alone), Group B (Bioner Bone, Bioner Sitemas Implantológicos), and Group C (unfilled defects). The animals were sacrificed at 4 and 8 weeks. Evaluation of the samples involved histological and histomorphometric analyses with radiographic evaluation. The histological evaluation showed a higher volume reduction in Group A compared with Group B (p < 0.05) and Control. Group A showed the highest values for cortical closure and bone formation around the particles, followed by Group B and Group C (p < 0.05). Within the limitations of this animal study, we can conclude that the use of human tooth particles leads to increased bone formation and reduced connective tissue in critical-size defects in rabbit calvaria when compared to BTCP biomaterial. The calvarial model is a robust base for the evaluation of different biomaterials.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.citationBioengineering, 2023, Vol. 10(6) : 638
dc.identifier.doihttps://doi.org/10.3390/bioengineering10060638
dc.identifier.issnElectronic: 2306-5354
dc.identifier.urihttp://hdl.handle.net/10201/154283
dc.languageenges
dc.publisherMDPI
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://www.mdpi.com/2306-5354/10/6/638
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBone graftes
dc.subjectBone substituteses
dc.subjectDentin grinderes
dc.subjectSkull rabbitses
dc.subjectTooth particleses
dc.titleThe use of human sterilized crushed tooth particles compared with BTCP biomaterial and empty defects in bone formation inside critical rabbit calvaria siteses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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