Publication: The use of human sterilized crushed tooth particles compared with BTCP biomaterial and empty defects in bone formation inside critical rabbit calvaria sites
Authors
Calvo Guirado, José Luis ; Cabo Pastor, Marta Belén ; Martínez Martínez, Francisco ; Garcés Villalá, Miguel Ángel ; Carlos Villafranca, Félix de ; García Carrillo, Nuria ; Fernández Domínguez, Manuel
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Publisher
MDPI
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DOI
https://doi.org/10.3390/bioengineering10060638
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info:eu-repo/semantics/article
Description
© 2023 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/
This document is the Published Manuscript version of a Published Work that appeared in final form in Bioengineering. To access the final edited and published work see https://doi.org/10.3390/bioengineering10060638
Abstract
This study aimed to assess the bone regeneration of critical-size defects in rabbit calvaria filled with freshly crushed extracted teeth, comparing them with BTCP biomaterial and empty sites. Materials and methods: Twenty-one female New Zealand rabbits were used in this study. Two critical-size defects 6 mm in size were created in the skull bone, each with a 3 mm separation between them. Three experimental groups were evaluated: Group A (human sterilized crushed teeth granules alone), Group B (Bioner Bone, Bioner Sitemas Implantológicos), and Group C (unfilled defects). The animals were sacrificed at 4 and 8 weeks. Evaluation of the samples involved histological and histomorphometric analyses with radiographic evaluation. The histological evaluation showed a higher volume reduction in Group A compared with Group B (p < 0.05) and Control. Group A showed the highest values for cortical closure and bone formation around the particles, followed by Group B and Group C (p < 0.05). Within the limitations of this animal study, we can conclude that the use of human tooth particles leads to increased bone formation and reduced connective tissue in critical-size defects in rabbit calvaria when compared to BTCP biomaterial. The calvarial model is a robust base for the evaluation of different biomaterials.
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Citation
Bioengineering, 2023, Vol. 10(6) : 638
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by/4.0/