Publication:
Expression of cannabinoid receptors in human kidney

Simple item page
dc.contributor.authorLarrinaga, Gorkaes
dc.contributor.authorVarona, Adolfoes
dc.contributor.authorPérez, Itxaro
dc.contributor.authorSanz, Begoña
dc.contributor.authorUgalde, Aitziber
dc.date.accessioned2015-09-29T07:18:19Z
dc.date.available2015-09-29T07:18:19Z
dc.date.issued2010
dc.description.abstractThe presence of CB1 and CB2 cannabinoid receptors and their physiological role in the kidney has been described in animal models but not in humans. Our aim in this study was to evaluate the presence of these receptors in human kidney, adult and fetal. For this purpose, RT-PCR, western-blot and immunohistochemical assays were performed. RT-PCR confirmed the presence of CB1 receptor mRNA receptor and the absence of the CB2 receptor mRNA in adult and fetal kidney. Western-blot and immunohistochemical assays revealed the presence of the CB1 cannabinoid receptor protein, which displayed a similar distribution in fetal and adult kidneys. Proximal and distal convoluted tubule cells and intercalated cells in the collecting ducts showed marked positivity. Conversely, the CB2 cannabinoid receptor protein was consistently negative in all cases. Our data suggest a possible implication of the endocannabinoid system in the physiology and development of the human kidney.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/46343
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectHuman kidneyes
dc.subjectImmunohistochemistryes
dc.subject.other616 - Patología. Medicina clínica. Oncologíaes
dc.titleExpression of cannabinoid receptors in human kidneyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Expression of cannabinoid receptors in human kidney.pdf
Size:
660.21 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Histology and histopathology Vol.25, nº9 (2010)